Family-based analysis of GGT1 and HNF1A gene polymorphisms in patients with polycystic ovary syndrome

被引：8

作者：

Xu, Xinghua ^{[1
,2
,3
,4
,5
]}

Qin, Lang ^{[1
,3
,4
,5
]}

Tian, Ye ^{[6
,7
]}

Wang, Min ^{[2
]}

Li, Guanyao ^{[8
]}

Du, Yanzhi ^{[6
,7
]}

Chen, Zi-Jiang ^{[1
,3
,4
,5
,6
,7
]}

Li, Weiping ^{[6
,7
,9
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Ctr Reprod Med, Jinan 250021, Shandong, Peoples R China

[2] Liaocheng Peoples Hosp, Dept Gynecol & Obstet, Liaocheng 252000, Shandong, Peoples R China

[3] Shandong Prov Key Lab Reprod Med, Jinan 250021, Shandong, Peoples R China

[4] Natl Res Ctr Assisted Reprod Technol & Reprod Gen, Jinan 250021, Shandong, Peoples R China

[5] Minist Educ, Key Lab Reprod Endocrinol, Jinan 250021, Shandong, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Ctr Reprod Med, Shanghai 200127, Peoples R China

[7] Shanghai Key Lab Assisted Reprod & Reprod Genet, Shanghai 200127, Peoples R China

[8] Liaocheng Peoples Hosp, Dept Hematol, Liaocheng 252000, Shandong, Peoples R China

[9] Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Obstet & Gynecol, Shanghai 200127, Peoples R China

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2018年 / 36卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

GGT1; gene; HNF1A gene; Polycystic ovary syndrome; Single-nucleotide polymorphism; Transmission disequilibrium test; GAMMA-GLUTAMYL-TRANSFERASE; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; CHROMOSOME; 2P16.3; RISK; TRANSPEPTIDASE; VARIANTS; DISEASE; WOMEN; 2P21;

D O I：

10.1016/j.rbmo.2017.10.107

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Polycystic ovary syndrome ( PCOS) is a complex endocrine-metabolic disease. Previous studies indicate that genes GGT1 and HNF1A may contribute to the abnormal glucose metabolism and altered lipid profile that are important clinical features of PCOS. In the current study, the correlation between polymorphisms in the GGT1 and HNF1A genes and PCOS was explored. A total of 310 family trios were studied and the transmission disequilibrium test (TDT) was used to assess the linkage between PCOS and three single-nucleotide polymorphisms (SNP) (rs4820599 of GGT1, rs7305618 and rs2393791 of HNF1A). No deviations from HWE were detected. None of the three SNP markers showed significant transmission disequilibrium in PCOS family trios (rs4820599: GGT1 gene, chi(2) = 1.067; rs7305618: HNF1A gene, chi(2) = 0.013; rs2393791: HNF1A gene, chi(2) = 0.031). In conclusion, no significant evidence supported a relationship between genes GGT1 and HNF1A and PCOS in the current family trios. (C) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

引用

页码：115 / 119

页数：5

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