Two new protostane-type triterpenoids from Alisma orientalis

被引：22
作者：
Xin, Xiu-Lan [1 ,2 ]
Zhao, Xin-Yu [2 ,3 ]
Huo, Xiao-Kui [2 ]
Tian, Xiang-Ge [4 ]
Sun, Cheng-Peng [2 ]
Zhang, Hou-Li [2 ]
Tian, Yan [2 ]
Liu, Yong [3 ]
Wang, Xun [5 ]
机构：
[1] Beijing Polytech, Coll Bioengn, Beijing, Peoples R China
[2] Dalian Med Univ, Coll Pharm, Key Lab Metab & Transport Liaoning, Dalian, Peoples R China
[3] Chinese Med Univ, Clin Lab Shengjing Hosp, Shenyang, Peoples R China
[4] Dalian Med Univ, Basic Med Coll, Dalian, Peoples R China
[5] Dalian Med Univ, Nondirectly Affliated Hosp, Peoples Hosp Dalian 3, Dept Nuerosurg, Dalian, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 02期
关键词：
Alisma orientalis; protostane-type triterpenoid; HCE-2; BIOLOGICAL-ACTIVE TRITERPENES; CARBOXYLESTERASE INHIBITORS; SUNFLOWER POLLEN; RHIZOME; SESQUITERPENES; DERIVATIVES; ACTIVATION; EXTRACT; ALISOLS;
D O I：
10.1080/14786419.2017.1344660
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new protostane-type triterpenoids, 17-epi alisolide (1) and 24-epi alismanol D (2), were isolated from Alisma orientalis together with one known compound. Their structural elucidations were conducted by NMR, UV and HRESIMS spectroscopic analyses, and comparison with the literature data. All the isolated compounds were evaluated for inhibitory effects on HCE-2. Compound 2 displayed moderate inhibitory activity against HCE-2 with IC50 value of 23.1M.
引用
收藏
页码：189 / 194
页数：6
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