Nickel-Catalyzed Allylation of a-Amido Sulfones To Form Protected Homoallylic Amines

被引：11
作者：
Caputo, Jill A. [1 ]
Naodovic, Marina [1 ]
Weix, Daniel J. [1 ]
机构：
[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA
来源：
SYNLETT | 2015年 / 26卷 / 03期
关键词：
nickel; allylation; amines; imines; reduction; TERT-BUTANESULFINYL IMINES; ASYMMETRIC ALLYLATION; MEDIATED ALLYLATION; ENANTIOSELECTIVE ALLYLATION; STEREOSELECTIVE-SYNTHESIS; REDUCTIVE ALLYLATION; ALLYLIC CARBONATES; AQUEOUS-MEDIA; IN-SITU; HYDRAZONES;
D O I：
10.1055/s-0034-1379539
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The allylation of stable, protected imine precursors, a-amiclo sulfones, with allylic acetates to form homoallylic amines is catalyzed by nickel under mild reducing conditions. Aliphatic and aryl imMes are tolerated, as are substituted allylic acetates. In the case of substituted allylic acetates, high diastereoselectivity and regioselectivity is observed in some cases and the branched product is obtained almost exclusively.
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收藏
页码：323 / 326
页数：4
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