DNA repair: Getting past a lesion - at a cost

被引：9

作者：

Bridges, BA ^{[1
]}

机构：

[1] Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England

来源：

CURRENT BIOLOGY | 1998年 / 8卷 / 24期

关键词：

D O I：

10.1016/S0960-9822(07)00552-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacteria survive many types of synthesis-blocking DNA lesion by inducing a number of proteins that enable their polymerases to synthesize past a lesion, albeit at the cost of an increased mutation rate. This process has now been convincingly achieved in vitro, opening the way to a fuller understanding of the mechanism.

引用

页码：R886 / R888

页数：3

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