Astrocyte barriers to neurotoxic inflammation

被引：914

作者：

Sofroniew, Michael V. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CENTRAL-NERVOUS-SYSTEM; SPINAL-CORD-INJURY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; BLOOD-BRAIN-BARRIER; FIBRILLARY ACIDIC PROTEIN; ADULT TRANSGENIC MICE; ALPHA-B-CRYSTALLIN; NF-KAPPA-B; REACTIVE ASTROCYTES; MULTIPLE-SCLEROSIS;

D O I：

10.1038/nrn3898

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Astrocytes form borders (glia limitans) that separate neural from non-neural tissue along perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function studies reveal that astrocyte borders and scars serve as functional barriers that restrict the entry of inflammatory cells into CNS parenchyma in health and disease. Astrocytes also have powerful pro-inflammatory potential. Thus, astrocytes are emerging as pivotal regulators of CNS inflammatory responses. This Review discusses evidence that astrocytes have crucial roles in attracting and restricting CNS inflammation, with important implications for diverse CNS disorders.

引用

页码：249 / 263

页数：15

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