Repeated fecal microbiota transplantation in a child with ulcerative colitis

被引：34

作者：

Shimizu, Hirotaka ^{[1
]}

Arai, Katsuhiro ^{[1
]}

Abe, Jun ^{[3
]}

Nakabayashi, Kazuhiko ^{[4
]}

Yoshioka, Takako ^{[2
]}

Hosoi, Kenji ^{[1
]}

Kuroda, Makoto ^{[5
]}

机构：

[1] Natl Ctr Child Hlth & Dev, Div Gastroenterol, Tokyo, Japan

[2] Natl Ctr Child Hlth & Dev, Dept Pathol, Tokyo, Japan

[3] Natl Res Inst Child Hlth & Dev, Dept Allergy & Immunol, Tokyo, Japan

[4] Natl Res Inst Child Hlth & Dev, Dept Maternal Fetal Biol, Tokyo, Japan

[5] Natl Inst Infect Dis, Pathogen Genom Ctr, Tokyo, Japan

来源：

PEDIATRICS INTERNATIONAL | 2016年 / 58卷 / 08期

关键词：

child; fecal microbiota transplantation; inflammatory bowel disease; pediatric; ulcerative colitis;

D O I：

10.1111/ped.12967

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report the case of an 11-year-old girl with ulcerative colitis refractory to conventional therapy, who was subsequently treated successfully with repeated fecal microbiota transplantation (FMT). The patient was steroid dependent despite several infliximab treatments, and colectomy was proposed to improve quality of life. After repeated FMT, she was able to maintain remission with on minimal dose of steroid. Although her fecal microbiota was dysbiotic before FMT, it was restored to a similar pattern as the donor after repeated FMT.

引用

页码：781 / 785

页数：5

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