Impact of Sublobar Resection on Pulmonary Function: Long-Term Results from American College of Surgeons Oncology Group Z4032 (Alliance)

被引：14

作者：

Kent, Michael S.

Mandrekar, Sumithra J.

Landreneau, Rodney

Nichols, Francis

DiPetrillo, Thomas A.

Meyers, Bryan

Heron, Dwight E.

Jones, David R.

Tan, Angelina D.

Starnes, Sandra

Putnam, Joe B., Jr.

Fernando, Hiran C.

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Surg, 330 Brookline Ave, Boston, MA 02215 USA

[2] Mayo Clin, Dept Hlth Sci Res, Alliance Stat & Data Ctr, Rochester, MN USA

[3] Allegheny Gen Hosp, Dept Surg, Pittsburgh, PA 15212 USA

[4] Mayo Clin, Dept Surg, Rochester, MN USA

[5] Rhode Isl Hosp, Dept Radiat Oncol, Providence, RI USA

[6] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA

[7] Univ Pittsburgh, Inst Canc, Dept Radiat Oncol, Pittsburgh, PA USA

[8] Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA

[9] Univ Cincinnati, Dept Surg, 231 Bethesda Ave, Cincinnati, OH 45267 USA

[10] Vanderbilt Univ, Dept Surg, Med Ctr, Nashville, TN 37240 USA

[11] Boston Med Ctr, Dept Surg, Boston, MA USA

来源：

ANNALS OF THORACIC SURGERY | 2016年 / 102卷 / 01期

关键词：

CELL LUNG-CANCER; RANDOMIZED-TRIAL; RISK; SEGMENTECTOMY; BRACHYTHERAPY; LOBECTOMY; RADIOTHERAPY; TUMORS;

D O I：

10.1016/j.athoracsur.2016.01.069

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background. Sublobar resection (SR) in high-risk operable patients may result in a long- term decrease in pulmonary function. We previously reported 3-month pulmonary function outcomes from a randomized phase III study of SR alone compared with SR with brachytherapy in patients with non-small cell lung cancer. We now report long-term pulmonary function after SR. Methods. Pulmonary function was measured at baseline and at 3, 12, and 24 months. A decline of 10% or more from baseline in the percentage predicted forced expiratory volume of 1 percentage or in the diffusion capacity of the lung for carbon monoxide was considered clinically meaningful. The effect of study arm, tumor location, size, approach (video-assisted thoracoscopic surgery vs thoracotomy), and SR type (wedge vs segmentectomy) on pulmonary function was assessed using a Wilcoxon rank sum test. A generalized estimating equation model was used to assess the effect of each factor on longitudinal data, including all four time points. Results. Complete pulmonary function data at all time points was available in 69 patients. No significant differences were observed in pulmonary function between SR and SR with brachytherapy, thus the study arms were combined for all analyses. A decline of 10% or more (p = 0.02) in the percentage predicted forced expiratory volume in 1 second was demonstrated for lower-lobe resections at 3 months but was not at 12 or 24 months. A decline of 10% or more (p = 0.05) in the percentage predicted diffusion capacity of the lung for carbon monoxide was seen for thoracotomy at 3 months but was not at 12 or 24 months. Conclusions. Clinically meaningful declines in pulmonary function occurred after lower lobe resection and after thoracotomy at 3 months but subsequently recovered. This study suggests that SR does not result in sustained decreased pulmonary function in high-risk operable patients. (C) 2016 by The Society of Thoracic Surgeons

引用

页码：230 / 238

页数：9

共 23 条

[1] LUNG-SCANNING AND EXERCISE TESTING FOR THE PREDICTION OF POSTOPERATIVE PERFORMANCE IN LUNG RESECTION CANDIDATES AT INCREASED RISK FOR COMPLICATIONS [J].

BOLLIGER, CT ;

WYSER, C ;

ROSER, H ;

SOLER, M ;

PERRUCHOUD, AP .

CHEST, 1995, 108 (02) :341-348

[2] Predicted versus observed FEV1 and DLCO after major lung resection:: A prospective evaluation at different postoperative periods [J].

Brunelli, Alessandro ;

Refai, Majed ;

Salati, Michele ;

Xiume, Francesco ;

Sabbatini, Armando .

ANNALS OF THORACIC SURGERY, 2007, 83 (03) :1134-1139

[3] Physiologic Evaluation of the Patient With Lung Cancer Being Considered for Resectional Surgery Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [J].

Brunelli, Alessandro ;

Kim, Anthony W. ;

Berger, Kenneth I. ;

Addrizzo-Harris, Doreen J. .

CHEST, 2013, 143 (05) :E166-E190

[4] Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials [J].

Chang, Joe Y. ;

Senan, Suresh ;

Paul, Marinus A. ;

Mehran, Reza J. ;

Louie, Alexander V. ;

Balter, Peter ;

Groen, Harry J. M. ;

McRae, Stephen E. ;

Widder, Joachim ;

Feng, Lei ;

van den Borne, Ben E. E. M. ;

Munsell, Mark F. ;

Hurkmans, Coen ;

Berry, Donald A. ;

van Werkhoven, Erik ;

Kresl, John J. ;

Dingemans, Anne-Marie ;

Dawood, Omar ;

Haasbeek, Cornelis J. A. ;

Carpenter, Larry S. ;

De Jaeger, Katrien ;

Komaki, Ritsuko ;

Slotman, Ben J. ;

Smit, Egbert F. ;

Roth, Jack A. .

LANCET ONCOLOGY, 2015, 16 (06) :630-637

[5] Radical cyberknife radiosurgery with tumor tracking: an effective treatment for inoperable small peripheral stage I non-small cell lung cancer [J].

Collins, Brian T. ;

Vahdat, Saloomeh ;

Erickson, Kelly ;

Collins, Sean P. ;

Suy, Simeng ;

Yu, Xia ;

Zhang, Ying ;

Subramaniam, Deepa ;

Reichner, Cristina A. ;

Sarikaya, Ismet ;

Esposito, Giuseppe ;

Yousefi, Shadi ;

Jamis-Dow, Carlos ;

Banovac, Filip ;

Anderson, Eric D. .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2009, 2

[6] STEREOTACTIC BODY RADIATION THERAPY FOR EARLY-STAGE NON-SMALL-CELL LUNG CARCINOMA: FOUR-YEAR RESULTS OF A PROSPECTIVE PHASE II STUDY [J].

Fakiris, Achilles J. ;

McGarry, Ronald C. ;

Yiannoutsos, Constantin T. ;

Papiez, Lech ;

Williams, Mark ;

Henderson, Mark A. ;

Timmerman, Robert .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 75 (03) :677-682

[7] Analysis of longitudinal quality-of-life data in high-risk operable patients with lung cancer: Results from the ACOSOG Z4032 (Alliance) multicenter randomized trial [J].

Fernando, Hiran C. ;

Landreneau, Rodney J. ;

Mandrekar, Sumithra J. ;

Nichols, Francis C. ;

DiPetrillo, Thomas A. ;

Meyers, Bryan F. ;

Heron, Dwight E. ;

Hillman, Shauna L. ;

Jones, David R. ;

Starnes, Sandra L. ;

Tan, Angelina D. ;

Daly, Benedict D. T. ;

Putnam, Joe B. .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2015, 149 (03) :718-725

[8] Impact of Brachytherapy on Local Recurrence Rates After Sublobar Resection: Results From ACOSOG Z4032 (Alliance), a Phase III Randomized Trial for High-Risk Operable Non-Small-Cell Lung Cancer [J].

Fernando, Hiran C. ;

Landreneau, Rodney J. ;

Mandrekar, Sumithra J. ;

Nichols, Francis C. ;

Hillman, Shauna L. ;

Heron, Dwight E. ;

Meyers, Bryan F. ;

DiPetrillo, Thomas A. ;

Jones, David R. ;

Starnes, Sandra L. ;

Tan, Angelina D. ;

Daly, Benedict D. T. ;

Putnam, Joe B., Jr. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (23) :2456-U246

[9] Thirty- and ninety-day outcomes after sublobar resection with and without brachytherapy for non-small cell lung cancer: Results from a multicenter phase III study [J].

Fernando, Hiran C. ;

Landreneau, Rodney J. ;

Mandrekar, Sumithra J. ;

Hillman, Shauna L. ;

Nichols, Francis C. ;

Meyers, Bryan ;

DiPetrillo, Thomas A. ;

Heron, Dwight E. ;

Jones, David R. ;

Daly, Benedict D. T. ;

Starnes, Sandra L. ;

Tan, Angelina ;

Putnam, Joe B. .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2011, 142 (05) :1143-1151

[10] The impact of adjuvant brachytherapy with sublobar resection on pulmonary function and dyspnea in high-risk patients with operable disease: Preliminary results from the American College of Surgeons Oncology Group Z4032 Trial [J].

Fernando, Hiran C. ;

Landreneau, Rodney J. ;

Mandrekar, Sumithra J. ;

Hillman, Shauna L. ;

Nichols, Francis C. ;

Meyers, Bryan ;

DiPetrillo, Thomas A. ;

Heron, Dwight ;

Jones, David R. ;

Daly, Benedict D. T. ;

Starnes, Sandra L. ;

Hatter, Jeffrey E. ;

Putnam, Joe B. .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2011, 142 (03) :554-562

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