Impact of PEGylated Nanoparticles on Tumor Targeted Drug Delivery

被引：60

作者：

Mozar, Fitya Syarifa ^{[1
]}

Chowdhury, Ezharul Hoque ^{[1
]}

机构：

[1] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Jalan Lagoon Selatan, Subang Jaya 47500, Selangor, Malaysia

来源：

CURRENT PHARMACEUTICAL DESIGN | 2018年 / 24卷 / 28期

关键词：

PEGylation; protein corona; pharmacokinetics; biodistribution; nanoparticles; tumor regression; tumor accumulation; ACCELERATED BLOOD CLEARANCE; POLYMERIC MICELLE FORMULATION; PHASE-II TRIAL; POLY(ETHYLENE GLYCOL); IN-VIVO; POLYETHYLENE-GLYCOL; GOLD NANOPARTICLES; CREMOPHOR-FREE; GENEXOL-PM; PROTEIN ADSORPTION;

D O I：

10.2174/1381612824666180730161721

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

PEG-functionalized nanoparticles as carriers of chemotherapeutics agents have been explored with notable successes in preclinical and clinical stages of cancer treatment, with some already approved by FDA, namely PEGylated liposomes and polymers. Half-life extension of therapeutic agents through PEGylation process improves their pharmacokinetic (PK) profiles, thereby reducing their dosing frequency. Protein corona composition of PEGylated nanoparticles (NPs) confers a tremendous influence on their surface characteristics which directly impact tumor accumulation and clearance properties of the drugs. By controlling the size and complexity of PEG molecules, as well as by attaching targeting moieties, the surface characteristics of NPs can be manipulated to improve their tumor uptake without sacrificing the circulation time. This review focuses on design and applications of PEGylated NPs for tumor targeted drug delivery in animal models and clinical setting.

引用

页码：3283 / 3296

页数：14

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