Inflammatory Biomarkers as Differential Predictors of Antidepressant Response

被引：101
作者：
Hashimoto, Kenji [1 ]
机构：
[1] Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba 2607680, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 04期
关键词：
antidepressant; biomarker; cytokine; inflammation; ketamine; predictor; response; DEPRESSION; PATHOPHYSIOLOGY; METAANALYSIS; CYTOKINES; KETAMINE; DRUGS; IL-6;
D O I：
10.3390/ijms16047796
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although antidepressants are generally effective in the treatment of major depressive disorder (MDD), it can still take weeks before patients feel the full antidepressant effects. Despite the efficacy of standard treatments, approximately two-thirds of patients with MDD fail to respond to pharmacotherapy. Therefore, the identification of blood biomarkers that can predict the treatment response to antidepressants would be highly useful in order to improve this situation. This article discusses inflammatory molecules as predictive biomarkers for antidepressant responses to several classes of antidepressants, including the N-methyl-d-aspartate (NMDA) receptor antagonist ketamine.
引用
收藏
页码：7796 / 7801
页数：6
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