Antioxidant Properties of the Manzamenones from the Tropical Marine Sponge Plakortis sp.

被引：2

作者：

Cho, MyoungLae ^{[1
,2
]}

Lee, Yeon-Ju ^{[1
]}

Lee, Jong Seok ^{[1
]}

Shin, Hee-Jae ^{[1
]}

Lee, Hyi-Seung ^{[1
]}

机构：

[1] Korea Inst Ocean Sci & Technol, Marine Nat Prod Chem Lab, Busan, South Korea

[2] Natl Dev Inst Korean Med Gyeongsan, Gyongsan, South Korea

来源：

NATURAL PRODUCT COMMUNICATIONS | 2020年 / 15卷 / 01期

关键词：

manzamenone; sponge; structural property; Plakortis; antioxidant; FATTY-ACID DERIVATIVES; ANALOGS;

D O I：

10.1177/1934578X19896694

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new manzamenone derivative (4) and four known manzamenones were isolated from the tropical marine sponge Plakortis sp. These compounds exhibited an improved inhibitory effect against the copper-induced low-density lipoprotein oxidation. To identify their structural properties for antioxidant effects, 43-O-methylmanzamenone A (2) has been exposed oxidative conditions such as hydrogen peroxide, mCPBA and primary alkyl amines to give various derivatives (6)-(9). The structures of the compounds were determined by spectroscopic analyses and comparison with literature values.

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页数：6

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