Genome-wide association study of quantitative resistance to southern leaf blight in the maize nested association mapping population

被引：411

作者：

Kump, Kristen L. ^{[1
]}

Bradbury, Peter J. ^{[2
,3
,4
]}

Wisser, Randall J. ^{[5
]}

Buckler, Edward S. ^{[2
,3
,4
]}

Belcher, Araby R. ^{[6
]}

Oropeza-Rosas, Marco A. ^{[1
]}

Zwonitzer, John C. ^{[6
]}

Kresovich, Stephen ^{[4
]}

McMullen, Michael D. ^{[7
,8
]}

Ware, Doreen ^{[4
]}

Balint-Kurti, Peter J. ^{[6
,9
]}

Holland, James B. ^{[1
,9
]}

机构：

[1] N Carolina State Univ, Dept Crop Sci, Raleigh, NC 27695 USA

[2] Cornell Univ, USDA ARS, Ithaca, NY 14853 USA

[3] Cornell Univ, Dept Genet & Plant Breeding, Ithaca, NY 14853 USA

[4] Cornell Univ, Inst Genom Divers, Ithaca, NY 14853 USA

[5] Univ Delaware, Dept Plant & Soil Sci, Newark, DE 19717 USA

[6] N Carolina State Univ, Dept Plant Pathol, Raleigh, NC 27695 USA

[7] Univ Missouri, USDA ARS, Columbia, MO 65211 USA

[8] Univ Missouri, Div Plant Sci, Columbia, MO 65211 USA

[9] USDA ARS, Raleigh, NC 27695 USA

来源：

NATURE GENETICS | 2011年 / 43卷 / 02期

基金：

美国国家科学基金会;

关键词：

INBRED LINE POPULATION; DISEASE RESISTANCE; TRANSCRIPTION FACTORS; TRAIT LOCI; GENETIC ARCHITECTURE; NEGATIVE REGULATOR; DEFENSE-RESPONSE; ARABIDOPSIS NPR1; PROTEIN-KINASES; FLOWERING TIME;

D O I：

10.1038/ng.747

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Nested association mapping (NAM) offers power to resolve complex, quantitative traits to their causal loci. The maize NAM population, consisting of 5,000 recombinant inbred lines (RILs) from 25 families representing the global diversity of maize, was evaluated for resistance to southern leaf blight (SLB) disease. Joint-linkage analysis identified 32 quantitative trait loci (QTLs) with predominantly small, additive effects on SLB resistance. Genome-wide association tests of maize HapMap SNPs were conducted by imputing founder SNP genotypes onto the NAM RILs. SNPs both within and outside of QTL intervals were associated with variation for SLB resistance. Many of these SNPs were within or near sequences homologous to genes previously shown to be involved in plant disease resistance. Limited linkage disequilibrium was observed around some SNPs associated with SLB resistance, indicating that the maize NAM population enables high-resolution mapping of some genome regions.

引用

页码：163 / U120

页数：7

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