ABCB1 Genotype and CSF β-Amyloid in Alzheimer Disease

被引：11

作者：

Kohen, R. ^{[1
]}

Shofer, J. B. ^{[2
]}

Korvatska, O. ^{[1
]}

Petrie, E. C. ^{[1
,2
]}

Wang, L. Y. ^{[1
,2
]}

Schellenberg, G. D. ^{[1
,3
]}

Peskind, E. R. ^{[1
,2
]}

Wilkinson, C. W. ^{[1
,3
]}

机构：

[1] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA

[2] VA Puget Sound Hlth Care Syst, MIRECC, Washington, DC USA

[3] Vet Affairs VA Puget Sound Hlth Care Syst, GRECC, Tacoma, WA USA

来源：

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY | 2011年 / 24卷 / 02期

关键词：

Alzheimer disease; dementia; P-glycoprotein; MDR1; ABCB1; association study; P-GLYCOPROTEIN EXPRESSION; BLOOD-BRAIN-BARRIER; RESISTANCE; TRANSPORT; POLYMORPHISMS; PATHOGENESIS; DEPOSITION;

D O I：

10.1177/0891988711402325

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood-brain barrier, where it mediates the efflux of beta-amyloid (A beta) from the brain. In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of A beta. No strong evidence for association was found.

引用

页码：63 / 66

页数：4

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