Latent Herpes Simplex Virus 1 Infection Does Not Induce Apoptosis in Human Trigeminal Ganglia

被引：5

作者：

Himmelein, Susanne ^{[1
,2
]}

Lindemann, Anja ^{[1
,2
]}

Sinicina, Inga ^{[3
]}

Strupp, Michael ^{[1
,2
]}

Brandt, Thomas ^{[2
,4
]}

Huefner, Katharina ^{[1
,2
]}

机构：

[1] Univ Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany

[2] Univ Munich, DSGZ, German Ctr Vertigo & Balance Disorders, Munich, Germany

[3] Univ Munich, Dept Legal Med, Munich, Germany

[4] Univ Munich, Klinikum Grosshadern, Inst Clin Neurosci, D-80539 Munich, Germany

来源：

JOURNAL OF VIROLOGY | 2015年 / 89卷 / 10期

关键词：

TYPE-1; LATENCY; TRANSCRIPT GENE; CELL-DEATH; REACTIVATION; HSV-1; ESTABLISHMENT; EXPRESSION;

D O I：

10.1128/JVI.03481-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpes simplex virus 1 (HSV-1) can establish lifelong latency in human trigeminal ganglia. Latently infected ganglia contain CD8(+) T cells, which secrete granzyme B and are thus capable of inducing neuronal apoptosis. Using immunohistochemistry and single-cell reverse transcription-quantitative PCR (RT-qPCR), higher frequency and transcript levels of caspase-3 were found in HSV-1-negative compared to HSV-1-positive ganglia and neurons, respectively. No terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) assay-positive neurons were detected. The infiltrating T cells do not induce apoptosis in latently infected neurons.

引用

页码：5747 / 5750

页数：4

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