Gene Expression Profiling for Discovery of Novel Targets in Human Traumatic Brain Injury

被引:10
|
作者
Barr, Taura L. [1 ,2 ]
Alexander, Sheila [3 ]
Conley, Yvette [3 ]
机构
[1] W Virginia Univ, Sch Nursing, Morgantown, WV 26506 USA
[2] W Virginia Univ, Ctr Neurosci, Morgantown, WV 26506 USA
[3] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA
基金
美国国家卫生研究院;
关键词
traumatic brain injury; gene expression profiling; genomics; biomarkers; BLOOD MONONUCLEAR-CELLS; MULTIPLE-SCLEROSIS PATIENTS; ACUTE ISCHEMIC-STROKE; CONTROL MAQC PROJECT; SUBSTANTIA-NIGRA; MICROARRAY ANALYSIS; PARKINSONS-DISEASE; GENOMIC RESPONSES; OLIGONUCLEOTIDE ARRAYS; ALZHEIMERS-DISEASE;
D O I
10.1177/1099800410385671
中图分类号
R47 [护理学];
学科分类号
1011 ;
摘要
Several clinical trials have failed to demonstrate a significant effect on outcome following human traumatic brain injury (TBI) despite promising results obtained in preclinical animal studies. These failures may be due in part to a misinterpretation of the findings obtained in preclinical animal models of TBI, a misunderstanding of the complexity of the human response to TBI, limited knowledge about the biological pathways that interact to contribute to good and bad outcomes after brain injury, and the effects of genomic variability and environment on individual recovery. Recent publications suggest that data obtained from gene expression profiling studies of complex neurological diseases such as stroke, multiple sclerosis (MS), Alzheimer's and Parkinson's may contribute to a more informed understanding of what affects outcome following TBI. These data may help to bridge the gap between successful preclinical studies and negative clinical trials in humans to reveal novel targets for therapy. Gene expression profiling has the capability to identify biomarkers associated with response to TBI, elucidate complex genetic interactions that may play a role in outcome following TBI, and reveal biological pathways related to brain health. This review highlights the current state of the literature on gene expression profiling for neurological disease and discusses its ability to aid in unraveling the variable human response to TBI and the potential for it to offer treatment strategies in an area where we currently have limited therapeutic options primarily based on supportive care.
引用
收藏
页码:140 / 153
页数:14
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