Influenza vaccine effectiveness within prospective cohorts of healthcare personnel in Israel and Peru 2016-2019

被引：7

作者：

Thompson, Mark G. ^{[1
]}

Soto, Giselle ^{[2
]}

Peretz, Alon ^{[3
,4
]}

Newes-Adeyi, Gabriella ^{[5
]}

Yoo, Young M. ^{[6
]}

Hirsch, Avital ^{[3
]}

Katz, Mark A. ^{[3
]}

Tinoco, Yeny ^{[2
]}

Avni, Yonat Shemer ^{[7
]}

Ticona, Eduardo ^{[8
]}

Malosh, Ryan ^{[9
]}

Martin, Emily ^{[9
]}

Matos, Eduardo ^{[10
]}

Reynolds, Sue ^{[1
]}

Wesley, Meredith ^{[5
]}

Ferdinands, Jill ^{[1
]}

Cheung, Angela ^{[5
]}

Levine, Min ^{[1
]}

Bravo, Eduar ^{[11
]}

Arriola, Carmen Sofia ^{[1
]}

Castillo, Maria Ester ^{[12
]}

Castro, Juan Carlos ^{[13
]}

Dawood, Fatimah ^{[1
]}

Greenberg, David ^{[7
]}

Quijandria, Joan Manuel Neyra ^{[2
]}

Azziz-Baumgartner, Eduardo ^{[1
]}

Monto, Arnold ^{[9
]}

Balicer, Ran D. ^{[3
]}

机构：

[1] Ctr Dis Control & Prevent CDC, Atlanta, GA USA

[2] US Naval Med Res Unit 6, Bellavista, Peru

[3] Clalit Res Inst, Tel Aviv, Israel

[4] Rabin Med Ctr, Petah Tiqwa, Israel

[5] ABT Associates Inc, Atlanta, GA USA

[6] Battelle Mem Inst, Atlanta, GA USA

[7] Ben Gurion Univ Negev, Soroka Univ, Med Ctr, Beer Sheva, Israel

[8] Dos Mayo Hosp, Lima, Peru

[9] Univ Michigan, Detroit, MI USA

[10] Hosp Loayza, Lima, Peru

[11] Hosp Nacl Cayetano Heredia, Lima, Peru

[12] Inst Salud Nino, Lima, Peru

[13] Hosp Carrion, Lima, Peru

来源：

VACCINE | 2021年 / 39卷 / 47期

关键词：

Healthcare; Influenza; Vaccine effectiveness; TEST-NEGATIVE DESIGN; ANTIBODY-RESPONSE; UNITED-STATES; VIRUS; ILLNESS; WORKERS; SEASON; METAANALYSIS; PROTECTION; COMMUNITY;

D O I：

10.1016/j.vaccine.2021.07.077

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: There are limited data on influenza vaccine effectiveness (IVE) in preventing laboratory confirmed influenza illness among healthcare personnel (HCP). Methods: HCP with direct patient contact working full-time in hospitals were followed during three influenza seasons in Israel (2016-2017 to 2018-2019) and Peru (2016 to 2018). Trivalent influenza vaccines were available at all sites, except during 2018-2019 when Israel used quadrivalent vaccines; vaccination was documented by electronic medical records, vaccine registries, and/or self-report (for vaccinations outside the hospital). Twice-weekly active surveillance identified acute respiratory symptoms or febrile illness (ARFI); self-collected respiratory specimens were tested by real-time reverse transcription polymerase chain reaction (PCR) assay. IVE was 100 x 1-hazard ratio (adjusted for sex, age, occupation, and hospital). Results: Among 5,489 HCP who contributed 10,041 person-seasons, influenza vaccination coverage was 47% in Israel and 32% in Peru. Of 3,056 ARFIs in Israel and 3,538 in Peru, A or B influenza virus infections were identified in 205 (7%) in Israel and 87 (2.5%) in Peru. IVE against all viruses across seasons was 1% (95% confidence interval [CI] =-30%, 25%) in Israel and 12% (95% CI =-61%, 52%) in Peru. Conclusion: Estimates of IVE were null using person-time models during six study seasons in Israel and Peru. (c) 2021 Published by Elsevier Ltd.

引用

页码：6956 / 6967

页数：12

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