Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats

被引：70
作者：
Terry, Alvin V., Jr. [1 ]
Kutiyanawalla, Ammar [2 ,3 ]
Pillai, Anilkumar [2 ,3 ]
机构：
[1] Med Coll Georgia, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA
[2] Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA
[3] Charlie Norwood VA Med Ctr, Med Res Serv, Augusta, GA 30904 USA
来源：
PHYSIOLOGY & BEHAVIOR | 2011年 / 102卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Aging; Alzheimer's disease; Cognition; Memory; NGF; proNGF; Neurotrophin; MORRIS WATER MAZE; MILD COGNITIVE IMPAIRMENT; LONG-TERM POTENTIATION; RECOGNITION MEMORY; FACTOR RECEPTORS; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; BASAL FOREBRAIN; PARIETAL CORTEX; PRO-NGF;
D O I：
10.1016/j.physbeh.2010.11.005
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
The objective of this study was to evaluate the effects of aging on the performance of specific memory-related tasks in rats as well as to determine the levels of several nerve growth factor (NGF)-related proteins in relevant brain regions. The results indicated age-related impairments in spatial learning in a water maze task as well as deficits in recognition memory in a Spontaneous Novel Object Recognition task. In the prefrontal cortex and hippocampus, aged rats (compared to young controls) had elevated levels of the proneurotrophin, proNGF (+1.8-1.9 fold), p75(NTR) receptors (+ 1.6-1.8 fold) and sortilin (+ 1.8-2.1 fold), and decreased levels of mature NGF (-36 to 44%), and phospho-TrkA receptors (-45 to 49%). The results of this study support the argument that NGF signaling is altered in the aging brain, and that such alterations may contribute to an age-related decline in cognitive function. These results may also help to identify specific components of the NGF-signaling pathway that could serve as targets for novel drug discovery and development for age-related disorders of cognition (e.g., Alzheimer's disease). (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：149 / 157
页数：9
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