Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy

被引：269

作者：

Yang, Nan ^{[1
]}

Xiao, Wanyue ^{[1
]}

Song, Xuejiao ^{[1
]}

Wang, Wenjun ^{[2
]}

Dong, Xiaochen ^{[1
,3
]}

机构：

[1] Nanjing Tech Univ Nanjing Tech, Sch Phys & Math Sci, Key Lab Flexible Elect KLOFE, Nanjing 211800, Peoples R China

[2] Nanjing Tech Univ Nanjing Tech, Sch Phys & Math Sci, Inst Adv Mat, Nanjing 211800, Peoples R China

[3] Liaocheng Univ, Sch Phys Sci & Informat Technol, Liaocheng 252059, Shandong, Peoples R China

来源：

NANO-MICRO LETTERS | 2020年 / 12卷 / 01期

关键词：

Tumor microenvironment; H2O2-responsive; Cancer; Nanomaterials; Photodynamic therapy; POLYMER MICELLES; VISIBLE-LIGHT; ALBUMIN-MNO2; NANOPARTICLES; HYPERBRANCHED POLYMER; CROSS-LINKING; GOLD; CHEMOTHERAPY; COMBINATION; OXIDATION; SELENIUM;

D O I：

10.1007/s40820-019-0347-0

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Photodynamic therapy (PDT), as one of the noninvasive clinical cancer phototherapies, suffers from the key drawback associated with hypoxia at the tumor microenvironment (TME), which plays an important role in protecting tumor cells from damage caused by common treatments. High concentration of hydrogen peroxide (H2O2), one of the hallmarks of TME, has been recognized as a double-edged sword, posing both challenges, and opportunities for cancer therapy. The promising perspectives, strategies, and approaches for enhanced tumor therapies, including PDT, have been developed based on the fast advances in H2O2-enabled theranostic nanomedicine. In this review, we outline the latest advances in H2O2-responsive materials, including organic and inorganic materials for enhanced PDT. Finally, the challenges and opportunities for further research on H2O2-responsive anticancer agents are envisioned.

引用

页数：27

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