CREB in adult neurogenesis - master and partner in the development of adult-born neurons?

被引：135
作者：
Merz, Katharina [1 ]
Herold, Sabine [1 ]
Lie, D. Chichung [1 ]
机构：
[1] German Res Ctr Environm Hlth, Res Grp Adult Neurogenesis & Neural Stem Cells, Inst Dev Genet, Helmholtz Zentrum Munchen, D-85764 Munich, Germany
来源：
EUROPEAN JOURNAL OF NEUROSCIENCE | 2011年 / 33卷 / 06期
关键词：
CREB; neurogenesis; signalling; transcription; ELEMENT-BINDING PROTEIN; LONG-TERM POTENTIATION; POSTNATAL SUBVENTRICULAR ZONE; NEWLY GENERATED NEURONS; GENOME-WIDE ANALYSIS; CAMP-RESPONSE; HIPPOCAMPAL NEUROGENESIS; GRANULE NEURONS; DEPENDENT TRANSCRIPTION; GENE-TRANSCRIPTION;
D O I：
10.1111/j.1460-9568.2011.07606.x
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The generation of new neurons in the adult brain is modulated by complex stimuli and a broad range of extrinsic signals. It remains a mystery how stem cells and their progeny integrate this wealth of regulatory input to generate a precise number of neurons that matches the physiological needs of the olfactory and hippocampal network. cAMP response element binding protein (CREB)-dependent signalling is controlling essential developmental steps in adult neurogenesis, i.e. survival, maturation and integration of new neurons. Here, we summarize the current knowledge on the function of CREB in adult neurogenesis and discuss the potential of CREB to integrate complex stimuli and to translate these into precise developmental processes in adult neurogenesis. The complex modulation of CREB-signalling may allow the adult neurogenic system to respond to stimuli in a fine-tuned rather than in an on-off fashion.
引用
收藏
页码：1078 / 1086
页数：9
相关论文
共 104 条
[1]  
Åberg MAI, 2000, J NEUROSCI, V20, P2896
[2]   A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos [J].
Ahn, S ;
Olive, M ;
Aggarwal, S ;
Krylov, D ;
Ginty, DD ;
Vinson, C .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (02) :967-977
[3]   Dendrite development regulated by CREST, a calcium-regulated transcriptional activator [J].
Aizawa, H ;
Hu, SC ;
Bobb, K ;
Balakrishnan, K ;
Ince, G ;
Gurevich, I ;
Cowan, M ;
Ghosh, A .
SCIENCE, 2004, 303 (5655) :197-202
[4]   Neuronal migration in the murine rostral migratory stream requires serum response factor [J].
Alberti, S ;
Krause, SM ;
Kretz, O ;
Philippar, U ;
Lemberger, T ;
Casanova, E ;
Wiebel, FF ;
Schwarz, H ;
Frotscher, M ;
Schütz, G ;
Nordheim, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (17) :6148-6153
[5]   The Creb1 coactivator Crtc1 is required for energy balance and fertility [J].
Altarejos, Judith Y. ;
Goebel, Naomi ;
Conkright, Michael D. ;
Inotiel, Hiroshi ;
Xie, Jianxin ;
Arias, Carlos M. ;
Sawchenko, Paul E. ;
Montminy, Marc .
NATURE MEDICINE, 2008, 14 (10) :1112-1117
[6]   The Heterogeneity of Adult Neural Stem Cells and the Emerging Complexity of Their Niche [J].
Alvarez-Buylla, A. ;
Kohwi, M. ;
Nguyen, T. M. ;
Merkle, F. T. .
CONTROL AND REGULATION OF STEM CELLS, 2008, 73 :357-+
[7]   Excitatory actions of GABA during development: The nature of the nurture [J].
Ben-Ari, Y .
NATURE REVIEWS NEUROSCIENCE, 2002, 3 (09) :728-739
[8]   Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior [J].
Bergami, Matteo ;
Rimondini, Roberto ;
Santi, Spartaco ;
Blum, Robert ;
Goetz, Magdalena ;
Canossa, Marco .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (40) :15570-15575
[9]   GABA release and uptake regulate neuronal precursor migration in the postnatal subventricular zone [J].
Bolteus, AJ ;
Bordey, A .
JOURNAL OF NEUROSCIENCE, 2004, 24 (35) :7623-7631
[10]   Interneurons Produced in Adulthood Are Required for the Normal Functioning of the Olfactory Bulb Network and for the Execution of Selected Olfactory Behaviors [J].
Breton-Provencher, Vincent ;
Lemasson, Morgane ;
Peralta, Modesto R., III ;
Saghatelyan, Armen .
JOURNAL OF NEUROSCIENCE, 2009, 29 (48) :15245-15257
12345678910