A New Triterpene Glucoside from Genista numidica

被引：1

作者：

Benayache, Feryal ^{[1
,2
]}

D'Ambola, Massimiliano ^{[2
]}

Cotugno, Roberta ^{[2
]}

Chaouche, Massika ^{[1
]}

Benayache, Samir ^{[1
]}

Benayache, Fadila ^{[1
]}

Braca, Alessandra ^{[3
]}

De Tommasi, Nunziatina ^{[2
]}

机构：

[1] Univ Constantine 1, Dept Chem, Res Unit, Dev Nat Resources,Bioact Mol & Physiochem & Biol, Constantine, Algeria

[2] Univ Salerno, Dipartimento Farm, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy

[3] Univ Pisa, Dipartimento Farm, Via Bonanno 33, I-56126 Pisa, Italy

来源：

NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 09期

关键词：

Genista numidica; Fabaceae; Triterpenoid glucoside; Cytotoxic activity; QUINOLIZIDINE ALKALOIDS; ANTIMICROBIAL ACTIVITY; CHEMICAL-COMPOSITION; ANTIOXIDANT ACTIVITY; ESSENTIAL OILS; FLAVONOIDS; SAPONINS; ULICINA;

D O I：

10.1177/1934578X1801300902

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new oleanolic acid triterpene glucoside, 3-O-beta-D-glucopyranosy1-3 beta,21 beta,28-trihydroxy-olean-12-en-27-oic acid (1), has been isolated together with twelve known compounds from the chloroform and ethyl acetate extracts of Genista numidica Spach (Fabaceae) aerial parts. The structures were elucidated by spectroscopic and spectrometric analyses, mainly 1D-, 2D-NMR and MS data, and comparison with the literature. The antiproliferative activity of isolates was investigated on Jurkat, HeLa, and MCF7 cell lines. The most active triterpene, 3-O-beta-D-glucopyranosyl-olean-12-en-3 beta,27,28,29-tetraol, showed activity in all cell lines. Further studies revealed that this compound induced in HeLa cells a cytostatic response.

引用

页码：1101 / 1104

页数：4

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