Molecular mechanisms of viral oncogenesis in humans

被引：200

作者：

Krump, Nathan A. ^{[1
]}

You, Jianxin ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2018年 / 16卷 / 11期

基金：

美国国家卫生研究院;

关键词：

EPSTEIN-BARR-VIRUS; MERKEL CELL POLYOMAVIRUS; SARCOMA-ASSOCIATED HERPESVIRUS; DNA-DAMAGE RESPONSE; NF-KAPPA-B; CLASS-I MOLECULES; INDUCED HEPATOCELLULAR-CARCINOMA; HUMAN-PAPILLOMAVIRUS TYPE-16; PRIMARY EFFUSION LYMPHOMA; KAPOSIS-SARCOMA;

D O I：

10.1038/s41579-018-0064-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Viral infection is a major contributor to the global cancer burden. Recent advances have revealed that seven known oncogenic viruses promote tumorigenesis through shared host cell targets and pathways. A comprehensive understanding of the principles of viral oncogenesis may enable the identification of unknown infectious aetiologies of cancer and the development of therapeutic or preventive strategies for virus-associated cancers. In this Review, we discuss the molecular mechanisms of viral oncogenesis in humans. We highlight recent advances in understanding how viral manipulation of host cellular signalling, DNA damage responses, immunity and microRNA targets promotes the initiation and development of cancer.

引用

页码：684 / 698

页数：15

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