Hepatitis B virus genotyping: current methods and clinical implications

被引：61
作者：
Guirgis, Bassem S. S. [1 ]
Abbas, Radwa O. [2 ]
Azzazy, Hassan M. E. [1 ,2 ]
机构：
[1] Amer Univ Cairo, Yousef Jameel Sci & Technol Res Ctr, New Cairo, Egypt
[2] Amer Univ Cairo, Dept Chem, New Cairo 11835, Egypt
来源：
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2010年 / 14卷 / 11期
关键词：
HBV genotype; Therapeutic response; Prognosis; Transplantation outcome; HBV transmission; Genotyping methods; REAL-TIME PCR; FRAGMENT-LENGTH-POLYMORPHISM; MELTING CURVE ANALYSIS; CHRONIC HBV INFECTION; MASS-SPECTROMETRIC ANALYSIS; HEPATOCELLULAR-CARCINOMA; LIVER-DISEASE; INTERFERON-ALPHA; CORE PROMOTER; VIRAL LOAD;
D O I：
10.1016/j.ijid.2010.03.020
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Hepatitis B virus (HBV) is a major cause of liver cirrhosis and hepatocellular carcinoma (HCC). Eight different HBV genotypes have been identified with distinct geographical distributions. Different genotyping methods exist including sequencing, INNO-LiPA, restriction fragment polymorphism (RFLP), multiplex PCR, serotyping, oligonucleotide microarray chips, reverse dot blot, restriction fragment mass polymorphism (RFMP), invader assay, and real-time PCR. Several investigators have studied the influence of HBV genotypes on clinical outcomes in chronic HBV patients. This review describes the current genotyping techniques, as well as their advantages and limitations. It also presents the clinical evidence that correlates HBV genotypes to clinical outcomes including disease severity, HCC development, response to therapy, disease chronicity, transplantation outcomes, and occult infection. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：E941 / E953
页数：13
相关论文
共 117 条
[11]   Subgenotypes of hepatitis B virus genotype D (D1, D2, D3 and D5) in India: differential pattern of mutations, liver injury and occult HBV infection [J].
Chandra, P. K. ;
Biswas, A. ;
Datta, S. ;
Banerjee, A. ;
Panigrahi, R. ;
Chakrabarti, S. ;
De, B. K. ;
Chakravarty, R. .
JOURNAL OF VIRAL HEPATITIS, 2009, 16 (10) :749-756
[12]   Improved multiplex-PCR to identify hepatitis B virus genotypes A-F and subgenotypes B1, B2, C1 and C2 [J].
Chen, Jinsong ;
Yin, Jianhua ;
Tan, Xiaojie ;
Zhang, Haiqin ;
Zhang, Hongwei ;
Chen, Beichuan ;
Chang, Wenjun ;
Schaefer, Stephan ;
Cao, Guangwen .
JOURNAL OF CLINICAL VIROLOGY, 2007, 38 (03) :238-243
[13]   Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C [J].
Chu, CJ ;
Hussain, M ;
Lok, ASF .
GASTROENTEROLOGY, 2002, 122 (07) :1756-1762
[14]   Influence of HLA-DRB1 alleles and HBV genotypes on interferon-α therapy for chronic hepatitis B [J].
Chu, Rui-Hai ;
Ma, Li-Xian ;
Wang, Gang ;
Shao, Li-Hua .
WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (30) :4753-4757
[15]   Preliminary results: Outcome of liver transplantation for hepatitis B virus varies by hepatitis B virus genotype [J].
Devarbhavi, HC ;
Cohen, AJ ;
Patel, R ;
Wiesner, RH ;
Dickson, RC ;
Ishitani, MB .
LIVER TRANSPLANTATION, 2002, 8 (06) :550-555
[16]   Subgenotype diversity of hepatitis B virus American genotype F in Amerindians from Venezuela and the general population of Colombia [J].
Devesa, M. ;
Loureiro, C. L. ;
Rivas, Y. ;
Monsalve, F. ;
Cardona, N. ;
Duarte, M. C. ;
Poblete, F. ;
Gutierrez, M. F. ;
Botto, C. ;
Pujol, F. H. .
JOURNAL OF MEDICAL VIROLOGY, 2008, 80 (01) :20-26
[17]   Hepatitis B virus genotype distribution among chronic hepatitis B virus carriers in Shanghai, China [J].
Ding, X ;
Mizokami, M ;
Yao, GB ;
Xu, B ;
Orito, E ;
Ueda, R ;
Nakanishi, M .
INTERVIROLOGY, 2001, 44 (01) :43-47
[18]  
El Khouri Marcelo, 2004, Rev. Hosp. Clin., V59, P216
[19]   Response to interferon alfa is hepatitis B virus genotype dependent:: genotype A is more sensitive to interferon than genotype D [J].
Erhardt, A ;
Blondin, D ;
Hauck, K ;
Sagir, A ;
Kohnle, T ;
Heintges, T ;
Häussinger, D .
GUT, 2005, 54 (07) :1009-1013
[20]  
Feitelson M A, 2001, ILAR J, V42, P127
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