Retrospective analysis of adult patients with acute lymphoblastic leukemia undergoing allogeneic hematopoietic cell transplantation: A multicenter experience of daily practice

被引：4

作者：

Tekgunduz, Emre ^{[1
]}

Kaynar, Leylagul ^{[2
]}

Goker, Hakan ^{[3
]}

Kaya, Ali Hakan ^{[1
]}

Turak, Esra Ermis ^{[2
]}

Eliacik, Eylem ^{[3
]}

Kayikci, Omur ^{[1
]}

Cetin, Mustafa ^{[2
]}

Buyukasik, Yahya ^{[3
]}

Eser, Bulent ^{[2
]}

Altuntas, Fevzi ^{[1
,4
]}

机构：

[1] Ankara Oncol Educ & Res Hosp, Hematol & Stem Cell Transplantat Clin, TR-06200 Ankara, Turkey

[2] Erciyes Univ, Fac Med, Dept Internal Med, Div Hematol, Kayseri, Turkey

[3] Hacettepe Univ, Fac Med, Dept Internal Med, Div Hematol, TR-06100 Ankara, Turkey

[4] Yildirim Beyazit Univ, Dept Internal Med, Div Hematol, Ankara, Turkey

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2016年 / 54卷 / 01期

关键词：

Acute lymphoblastic leukemia; ALL; Hematopoietic cell transplantation; Allogeneic; HCT; BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; CLINICAL-TRIALS; THERAPY; SURVIVAL; METAANALYSIS; DIAGNOSIS; REGIMENS; LIVER; INDEX;

D O I：

10.1016/j.transci.2016.01.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Compared to pediatric age group, the prognosis of adult acute lymphoblastic leukemia (ALL) is still dismal even in patients receiving allogeneic hematopoietic cell transplantation (AHCT). We retrospectively analyzed 205 adults (male: 122; female: 83) with ALL who underwent AHCT. Median age of patients was 28 (18-59). Fifty-two patients had Ph+ ALL. The estimated relapse free and overall survival (OS) of the study cohort at 1, 2 and 3 years were 52.3%/63.9%, 42.9%/49.5% and 39.9%/45.6%, respectively. On multivariate analysis, first complete remission at the time of AHCT, TBI-based conditioning and development of chronic graft-versus-host disease were only factors, which were significantly associated with prolonged OS. (c) 2016 Elsevier Ltd. All rights reserved.

引用

页码：41 / 47

页数：7

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