Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections

被引：36

作者：

Crum-Cianflone, Nancy F. ^{[1
,2
,4
]}

Lam, Pamela V. ^{[1
]}

Ross-Walker, Sarah ^{[3
]}

Rosen, Lindsey B. ^{[5
]}

Holland, Steven M. ^{[5
]}

机构：

[1] Scripps Mercy Hosp, Dept Internal Med, San Diego, CA 92103 USA

[2] Scripps Mercy Hosp, Div Infect Dis, San Diego, CA 92103 USA

[3] Scripps Mercy Hosp, Dept Pharm, San Diego, CA 92103 USA

[4] Naval Med Ctr San Diego, Div Infect Dis, San Diego, CA USA

[5] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2017年 / 4卷 / 04期

关键词：

cryptococcus; GM-CSF autoantibodies; immune deficits; spinal epidural abscess; CHRONIC MUCOCUTANEOUS CANDIDIASIS; PULMONARY ALVEOLAR PROTEINOSIS; IFN-GAMMA AUTOANTIBODY; GM-CSF AUTOANTIBODIES; RITUXIMAB THERAPY; DISEASE;

D O I：

10.1093/ofid/ofx211

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunologic evaluation for anti-GM-CSF antibodies may be important to inform management and counseling.

引用

页数：6

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