SUMOylation and de-SUMOylation in response to DNA damage

被引：73

作者：

Dou, Hong ^{[2
]}

Huang, Chao ^{[1
]}

Thang Van Nguyen ^{[2
]}

Lu, Long-Sheng ^{[1
]}

Yeh, Edward T. H. ^{[1
,2
]}

机构：

[1] St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Cardiol, Houston, TX 77030 USA

来源：

FEBS LETTERS | 2011年 / 585卷 / 18期

关键词：

SUMO; SENP; RPA; Repair; Replication; REPLICATION PROTEIN-A; DOUBLE-STRAND BREAKS; CONJUGATING ENZYME UBC9; HOMOLOGOUS RECOMBINATION; SUMO MODIFICATION; ATAXIA-TELANGIECTASIA; RAD52; SUMOYLATION; REDOX REGULATION; STRUCTURAL BASIS; UBIQUITIN;

D O I：

10.1016/j.febslet.2011.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR). (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2891 / 2896

页数：6

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