Sweet Bones: The Pathogenesis of Bone Alteration in Diabetes

被引:32
作者
Al-Hariri, Mohammed [1 ]
机构
[1] Univ Dammam, Dept Physiol, Coll Med, POB 2114-31451, Dammam, Saudi Arabia
关键词
FALL-RELATED FRACTURES; GROWTH-FACTOR-I; MINERAL DENSITY; INSULIN; MELLITUS; TYPE-1; TURNOVER; RISK; OSTEOPENIA; COLLAGEN;
D O I
10.1155/2016/6969040
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diabetic patients have increased fracture risk. The pathogenesis underlying the status of bone alterations in diabetes mellitus is not completely understood but is multifactorial. The major deficits appear to be related to a deficit in mineralized surface area, a decrement in the rate of mineral apposition, deceased osteoid surface, depressed osteoblast activity, and decreased numbers of osteoclasts due to abnormal insulin signaling pathway. Other prominent features of diabetes mellitus are an increased urinary excretion of calcium and magnesium, accumulation of advanced glycation end products, and oxidative stress leading to sweet bones (altered bone's strength, metabolism, and structure). Every diabetic patient should be assessed for risk factors for fractures and osteoporosis. The pathogenesis of the bone alterations in diabetes mellitus as well as their molecular mechanisms needs further study.
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页数:5
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