Near-Infrared Fluorescence Imaging in Patients Undergoing Pancreaticoduodenectomy

被引：68

作者：

Hutteman, M. ^{[1
]}

van der Vorst, J. R. ^{[1
]}

Mieog, J. S. D. ^{[1
]}

Bonsing, B. A. ^{[1
]}

Hartgrink, H. H. ^{[1
]}

Kuppen, P. J. K. ^{[1
]}

Lowik, C. W. G. M. ^{[2
]}

Frangioni, J. V. ^{[3
,4
]}

van de Velde, C. J. H. ^{[1
]}

Vahrmeijer, A. L. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Endocrinol, Leiden, Netherlands

[3] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

[4] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA

来源：

EUROPEAN SURGICAL RESEARCH | 2011年 / 47卷 / 02期

关键词：

Bile duct imaging; Bile duct reconstruction; Image-guided surgery; Indocyanine green; Near-infrared fluorescence imaging; Pancreatic surgery; MACROMOLECULAR THERAPEUTICS; DUCTAL ADENOCARCINOMA; CURATIVE RESECTION; INDOCYANINE GREEN; CANCER; IDENTIFICATION; TUMORS; PERMEABILITY; RECURRENCE;

D O I：

10.1159/000329411

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Intraoperative visualization of pancreatic tumors has the potential to improve radical resection rates. Intraoperative visualization of the common bile duct and bile duct anastomoses could be of added value. In this study, we explored the use of indocyanine green (ICG) for these applications and attempted to optimize injection timing and dose. Methods: Eight patients undergoing a pancreaticoduodenectomy were injected intravenously with 5 or 10 mg ICG. During and after injection, the pancreas, tumor, common bile duct and surrounding organs were imaged in real time using the Mini-FLARE TM near-infrared (NIR) imaging system. Results: No clear tumor-to-pancreas contrast was observed, except for incidental contrast in 1 patient. The common bile duct was clearly visualized using NIR fluorescence, within 10 min after injection, with a maximal contrast between 30 and 90 min after injection. Patency of biliary anastomoses could be visualized due to biliary excretion of ICG. Conclusion: No useful tumor demarcation could be visualized in pancreatic cancer patients after intravenous injection of ICG. However, the common bile duct and biliary anastomoses were clearly visualized during the observation period. Therefore, these imaging strategies could be beneficial during biliary surgery in cases where the surgical anatomy is aberrant or difficult to identify. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：90 / 97

页数：8

共 35 条

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