Knowledge-based repositioning of the anti-HCV direct antiviral agent Sofosbuvir as SARS-CoV-2 treatment

被引：12

作者：

Buonaguro, Luigi ^{[1
]}

Buonaguro, Franco M. ^{[2
]}

机构：

[1] Fdn Pascale IRCCS, Ist Nazl Studio & Cura Tumori, Lab Innovat Immunol Models, Via Mariano Semmola 1, I-80131 Naples, Italy

[2] Fdn Pascale IRCCS, Ist Nazl Studio & Cura Tumori, Lab Mol Biol & Viral Oncol, Via Mariano Semmola 52, I-80131 Naples, Italy

来源：

INFECTIOUS AGENTS AND CANCER | 2020年 / 15卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

D O I：

10.1186/s13027-020-00302-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The new human coronavirus named SARS-CoV-2 is a positive-sense RNA virus for which no specific drugs are currently available. A knowledge-based analysis strongly suggests a possible repositioning of the anti-HCV direct antiviral agent (DAA) Sofosbuvir as treatment for SARS-CoV-2. Indeed, the RNA-dependent RNA-polymerases (RdRp) of the two viruses show high sequence and structural homology, supporting the likelihood of binding the Sofosbuvir molecule with similar efficiency. Such a repositioning would allow the containment of the SARS-CoV-2 pandemic and limit the progression of disease to potentially deadly COVID19.

引用

页数：3

共 18 条

[1] Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease [J].

Agostini, Maria L. ;

Andres, Erica L. ;

Sims, Amy C. ;

Graham, Rachel L. ;

Sheahan, Timothy P. ;

Lu, Xiaotao ;

Smith, Everett Clinton ;

Case, James Brett ;

Feng, Joy Y. ;

Jordan, Robert ;

Ray, Adrian S. ;

Cihlar, Tomas ;

Siegel, Dustin ;

Mackman, Richard L. ;

Clarke, Michael O. ;

Baric, Ralph S. ;

Denison, Mark R. .

MBIO, 2018, 9 (02)

[2] Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper [J].

Boettler, Tobias ;

Newsome, Philip N. ;

Mondelli, Mario U. ;

Maticic, Mojca ;

Cordero, Elisa ;

Cornberg, Markus ;

Berg, Thomas .

JHEP REPORTS, 2020, 2 (03)

[3] Potential for global spread of a novel coronavirus from China [J].

Bogoch, Isaac I. ;

Watts, Alexander ;

Thomas-Bachli, Andrea ;

Huber, Carmen ;

Kraemer, Moritz U. G. ;

Khan, Kamran .

JOURNAL OF TRAVEL MEDICINE, 2020, 27 (02)

[4] Hepatitis C virus therapy: No one will be left behind [J].

Bourliere, Marc ;

Pietri, Olivia .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2019, 53 (06) :755-760

[5] SARS-CoV-2 RNA polymerase as target for antiviral therapy [J].

Buonaguro, Luigi ;

Tagliamonte, Maria ;

Tornesello, Maria Lina ;

Buonaguro, Franco M. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2020, 18 (01)

[6]

Chan K. S., 2003, Hong Kong Medical Journal, V9, P399

[7] A systematic review on the ef ficacy and safety of chloroquine for the treatment of COVID-19 [J].

Cortegiani, Andrea ;

Ingoglia, Giulia ;

Ippolito, Mariachiara ;

Giarratano, Antonino ;

Einav, Sharon .

JOURNAL OF CRITICAL CARE, 2020, 57 :279-283

[8] Anti-HCV, nucleotide inhibitors, repurposing against COVID-19 [J].

Elfiky, Abdo A. .

LIFE SCIENCES, 2020, 248

[9] The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China [J].

Hui, David S. ;

Azhar, Esam I. ;

Madani, Tariq A. ;

Ntoumi, Francine ;

Kock, Richard ;

Dar, Osman ;

Ippolito, Giuseppe ;

Mchugh, Timothy D. ;

Memish, Ziad A. ;

Drosten, Christian ;

Zumla, Alimuddin ;

Petersen, Eskild .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 91 :264-266

[10] Structural Analysis of Monomeric RNA-Dependent Polymerases: Evolutionary and Therapeutic Implications [J].

Jacome, Rodrigo ;

Becerra, Arturo ;

Ponce de Leon, Samuel ;

Lazcano, Antonio .

PLOS ONE, 2015, 10 (09)

← 1 2 →