One-Pot Synthesis of Indolizines via Sequential Rhodium-Catalyzed [2+1]-Cyclopropanation, Palladium-Catalyzed Ring Expansion, and Oxidation Reactions from Pyridotriazoles and 1,3-Dienes

被引：49

作者：

Kim, Hyunseok ^{[1
]}

Kim, Sanghyuck ^{[1
]}

Kim, Jiyeon ^{[1
]}

Son, Jeong-Yu ^{[1
]}

Baek, Yonghyeon ^{[1
]}

Um, Kyusik ^{[1
]}

Lee, Phil Ho ^{[1
]}

机构：

[1] Kangwon Natl Univ, Dept Chem, Chunchon 24341, South Korea

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 20期

基金：

新加坡国家研究基金会;

关键词：

PYRROLE-CONTAINING HETEROCYCLES; 2-(PYRIDIN-2-YL)ACETATE DERIVATIVES; TRANSANNULATION REACTION; EFFICIENT SYNTHESIS; TERMINAL ALKYNES; C-C; ACTIVATION; CYCLIZATION; NITRILES; ALKENES;

D O I：

10.1021/acs.orglett.7b02826

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, one-pot synthetic method for producing functionalized indolizine derivatives was developed via a Rh-catalyzed [2 + 1]-cyclopropanation, Pd-catalyzed ring expansion, and subsequent Oxidation using manganese dioxide from pridotriazoles and 1,3-dienes.

引用

页码：5677 / 5680

页数：4

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