One-Pot Synthesis of Indolizines via Sequential Rhodium-Catalyzed [2+1]-Cyclopropanation, Palladium-Catalyzed Ring Expansion, and Oxidation Reactions from Pyridotriazoles and 1,3-Dienes

被引：49
|
作者：
Kim, Hyunseok [1 ]
Kim, Sanghyuck [1 ]
Kim, Jiyeon [1 ]
Son, Jeong-Yu [1 ]
Baek, Yonghyeon [1 ]
Um, Kyusik [1 ]
Lee, Phil Ho [1 ]
机构：
[1] Kangwon Natl Univ, Dept Chem, Chunchon 24341, South Korea
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 20期
基金：
新加坡国家研究基金会;
关键词：
PYRROLE-CONTAINING HETEROCYCLES; 2-(PYRIDIN-2-YL)ACETATE DERIVATIVES; TRANSANNULATION REACTION; EFFICIENT SYNTHESIS; TERMINAL ALKYNES; C-C; ACTIVATION; CYCLIZATION; NITRILES; ALKENES;
D O I：
10.1021/acs.orglett.7b02826
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, one-pot synthetic method for producing functionalized indolizine derivatives was developed via a Rh-catalyzed [2 + 1]-cyclopropanation, Pd-catalyzed ring expansion, and subsequent Oxidation using manganese dioxide from pridotriazoles and 1,3-dienes.
引用
收藏
页码：5677 / 5680
页数：4
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