Early B-cell factor regulates the expression of Hemokinin-1 in the olfactory epithelium and differentiating B lymphocytes

被引：5

作者：

Tran, Anne H. ^{[1
,2
]}

Berger, Alexandra ^{[1
,2
]}

Wu, Gillian E. ^{[2
]}

Kee, Barbara L. ^{[3
]}

Paige, Christopher J. ^{[1
,2
]}

机构：

[1] Princess Margaret Hosp, Dept Stem Cell & Dev Biol, Ontario Canc Inst, Univ Hlth Network, Toronto, ON M5G 2M9, Canada

[2] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

[3] Univ Chicago, Dept Pathol, Comm Immunol, Chicago, IL 60637 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 232卷 / 1-2期

关键词：

Hemokinin-1; Tachykinin; B cell differentiation; Main olfactory epithelium; Early B-cell factor; Olfactory neuron-specific transcription factor; HEMATOPOIETIC STEM-CELLS; P-LIKE FUNCTION; SUBSTANCE-P; TRANSCRIPTION FACTORS; NEURONAL DIFFERENTIATION; GENE-EXPRESSION; DENDRITIC CELLS; BONE-MARROW; T-CELL; RECEPTOR;

D O I：

10.1016/j.jneuroim.2010.09.027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hemokinin-1, encoded by the TAC4 gene, is a tachykinin most closely related to substance P. Previous studies have shown that TAC4 distinguishes itself from other tachykinins by its predominantly non-neuronal expression profile, particularly in cells of the immune system. Here we report for the first time that the highest levels of TAC4 expression are found in the olfactory epithelium. Furthermore, we identify olfactory neuron-specific transcription factor (Olf-1), also known as early B-cell factor (EBF), as a novel regulator of TAC4 expression. EBF present in the olfactory epithelium and in B cells binds to two sites in the TAC4 promoter and modulates expression in developing B cells. Our findings suggest a role for TAC4 in cell differentiation, and represent a regulatory bridge between the nervous system and the immune system. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：41 / 50

页数：10

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