Hypothermia for Reduction of Myocardial Reperfusion Injury in Acute Myocardial Infarction Closing the Translational Gap

被引：16
作者：
El Farissi, Mohamed [1 ]
Keulards, Danielle C. J. [1 ]
Zelis, Jo M. [1 ]
van't Veer, Marcel [1 ]
Zimmermann, Frederik M. [1 ]
Pijls, Nico H. J. [1 ]
Otterspoor, Luuk C. [1 ]
机构：
[1] Catharina Hosp, Dept Cardiol, Michelangelolaan 2, NL-3584 CX Eindhoven, Netherlands
来源：
CIRCULATION-CARDIOVASCULAR INTERVENTIONS | 2021年 / 14卷 / 08期
关键词：
hypothermia; myocardial infarction; percutaneous coronary intervention; reperfusion; PERCUTANEOUS CORONARY INTERVENTION; POOLED ANALYSIS; ISCHEMIA; TEMPERATURE; PRESERVES; SIZE; THROMBOLYSIS; TERMINATION; MANAGEMENT; RESPONSES;
D O I：
10.1161/CIRCINTERVENTIONS.120.010326
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myocardial reperfusion injury-triggered by an inevitable inflammatory response after reperfusion-may undo a considerable part of the myocardial salvage achieved through timely percutaneous coronary intervention in patients with acute myocardial infarction. Because infarct size is strongly correlated to mortality and risk of heart failure, the importance of endeavors for cardioprotective therapies to attenuate myocardial reperfusion injury and decrease infarct size remains undisputed. Myocardial reperfusion injury is the result of several complex nonlinear phenomena, and for a therapy to be effective, it should act on multiple targets involved in this injury. In this regard, hypothermia remains a promising treatment despite a number of negative randomized controlled trials in humans with acute myocardial infarction so far. To turn the tide for hypothermia in patients with acute myocardial infarction, sophisticated solutions for important limitations of systemic hypothermia should continue to be developed. In this review, we provide a comprehensive overview of the pathophysiology and clinical expression of myocardial reperfusion injury and discuss the current status and possible future of hypothermia for cardioprotection in patients with acute myocardial infarction.
引用
收藏
页码：864 / 872
页数：9
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