Hypothermia for Reduction of Myocardial Reperfusion Injury in Acute Myocardial Infarction Closing the Translational Gap

被引：14
作者：
El Farissi, Mohamed [1 ]
Keulards, Danielle C. J. [1 ]
Zelis, Jo M. [1 ]
van't Veer, Marcel [1 ]
Zimmermann, Frederik M. [1 ]
Pijls, Nico H. J. [1 ]
Otterspoor, Luuk C. [1 ]
机构：
[1] Catharina Hosp, Dept Cardiol, Michelangelolaan 2, NL-3584 CX Eindhoven, Netherlands
来源：
CIRCULATION-CARDIOVASCULAR INTERVENTIONS | 2021年 / 14卷 / 08期
关键词：
hypothermia; myocardial infarction; percutaneous coronary intervention; reperfusion; PERCUTANEOUS CORONARY INTERVENTION; POOLED ANALYSIS; ISCHEMIA; TEMPERATURE; PRESERVES; SIZE; THROMBOLYSIS; TERMINATION; MANAGEMENT; RESPONSES;
D O I：
10.1161/CIRCINTERVENTIONS.120.010326
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myocardial reperfusion injury-triggered by an inevitable inflammatory response after reperfusion-may undo a considerable part of the myocardial salvage achieved through timely percutaneous coronary intervention in patients with acute myocardial infarction. Because infarct size is strongly correlated to mortality and risk of heart failure, the importance of endeavors for cardioprotective therapies to attenuate myocardial reperfusion injury and decrease infarct size remains undisputed. Myocardial reperfusion injury is the result of several complex nonlinear phenomena, and for a therapy to be effective, it should act on multiple targets involved in this injury. In this regard, hypothermia remains a promising treatment despite a number of negative randomized controlled trials in humans with acute myocardial infarction so far. To turn the tide for hypothermia in patients with acute myocardial infarction, sophisticated solutions for important limitations of systemic hypothermia should continue to be developed. In this review, we provide a comprehensive overview of the pathophysiology and clinical expression of myocardial reperfusion injury and discuss the current status and possible future of hypothermia for cardioprotection in patients with acute myocardial infarction.
引用
收藏
页码：864 / 872
页数：9
相关论文
共 49 条
  • [1] Role of the cardiac Na+ /H+ exchanger during ischemia and reperfusion
    Allen, DG
    Xiao, XH
    [J]. CARDIOVASCULAR RESEARCH, 2003, 57 (04) : 934 - 941
  • [2] Effects of endovascular cooling on infarct size in ST-segment elevation myocardial infarction: A patient-level pooled analysis from randomized trials
    Dae, Michael
    O'Neill, William
    Grines, Cindy
    Dixon, Simon
    Erlinge, David
    Noc, Marko
    Holzer, Michael
    Dee, Anne
    [J]. JOURNAL OF INTERVENTIONAL CARDIOLOGY, 2018, 31 (03) : 269 - 276
  • [3] Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs
    Dae, MW
    Gao, DW
    Sessler, DI
    Chair, K
    Stillson, CA
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2002, 282 (05): : H1584 - H1591
  • [4] Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury JACC Review Topic of the Week
    Davidson, Sean M.
    Ferdinandy, Peter
    Andreadou, Ioanna
    Botker, Hans Erik
    Heusch, Gerd
    Ibanez, Borja
    Ovize, Michel
    Schulz, Rainer
    Yellon, Derek M.
    Hausenloy, Derek J.
    Garcia-Dorado, David
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 73 (01) : 89 - 99
  • [5] Relationship between microvascular obstruction and adverse events following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials
    de Waha, Suzanne
    Patel, Manesh R.
    Granger, Christopher B.
    Ohman, E. Magnus
    Maehara, Akiko
    Eitel, Ingo
    Ben-Yehuda, Ori
    Jenkins, Paul
    Thiele, Holger
    Stone, Gregg W.
    [J]. EUROPEAN HEART JOURNAL, 2017, 38 (47) : 3502 - +
  • [6] Mitochondria and cardioprotection
    Di Lisa, Fabio
    Canton, Marcella
    Menabo, Roberta
    Kaludercic, Nina
    Bernardi, Paolo
    [J]. HEART FAILURE REVIEWS, 2007, 12 (3-4) : 249 - 260
  • [7] Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction
    Dixon, SR
    Whitbourn, RJ
    Dae, MW
    Grube, E
    Sherman, W
    Schaer, GL
    Jenkins, S
    Baim, DS
    Gibbons, RJ
    Kuntz, RE
    Popma, JJ
    Nguyen, TT
    O'Neill, WW
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (11) : 1928 - 1934
  • [8] Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction. Rationale and design of the EURO-ICE trial
    El Farissi, Mohamed
    Keulards, Danielle C. J.
    van 't Veer, Marcel
    Zelis, Jo M.
    Berry, Colin
    De Bruyne, Bernard
    Engstrom, Thomas
    Frobert, Ole
    Piroth, Zsolth
    Oldroyd, Keith G.
    Tonino, Pim A. L.
    Pijls, Nico H. J.
    Otterspoor, Luuk C.
    [J]. EUROINTERVENTION, 2021, 16 (17) : 1444 - +
  • [9] ENGLER RL, 1983, AM J PATHOL, V111, P98
  • [10] Rapid Endovascular Catheter Core Cooling Combined With Cold Saline as an Adjunct to Percutaneous Coronary Intervention for the Treatment of Acute Myocardial Infarction The CHILL-MI Trial: A Randomized Controlled Study of the Use of Central Venous Catheter Core Cooling Combined With Cold Saline as an Adjunct to Percutaneous Coronary Intervention for the Treatment of Acute Myocardial Infarction
    Erlinge, David
    Gotberg, Matthias
    Lang, Irene
    Holzer, Michael
    Noc, Marko
    Clemmensen, Peter
    Jensen, Ulf
    Metzler, Bernhard
    James, Stefan
    Botker, Hans Erik
    Omerovic, Elmir
    Engblom, Henrik
    Carlsson, Marcus
    Arheden, Hakan
    Ostlund, Ollie
    Wallentin, Lars
    Harnek, Jan
    Olivecrona, Goran K.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (18) : 1857 - 1865
12345