Cowpea mosaic virus as a vaccine carrier of heterologous antigens

被引：42
作者：
Brennan, FR
Jones, TD
Hamilton, WDO
机构：
[1] Proteom Ltd., Babraham Hall, Babrahm
来源：
MOLECULAR BIOTECHNOLOGY | 2001年 / 17卷 / 01期
关键词：
plant virus; chimeric virus particle; vaccine;
D O I：
10.1385/MB:17:1:15
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The plant virus, cowpea mosaic virus (CPMV), has been developed as an expression and presentation system to display antigenic epitopes: derived from a number of vaccine targets including infectious disease agents and tumors. These chimeric virus particles (CVPs) could represent a cost-effective and safe alternative to live replicating virus and bacterial vaccines. A number of CVPs have now been generated and their immunogenicity examined ill a number of animal species. This review details the humoral and cellular immune responses generated by these CVPs following both par-enteral and mucosal delivery and highlights the potential of CVPs to elicit protective immunity from both viral and bacterial infection.
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收藏
页码：15 / 26
页数：12
相关论文
共 103 条
[51]  
Kensil CR, 1996, CRIT REV THER DRUG, V13, P1
[52]  
KLAUS GGB, 1979, IMMUNOLOGY, V38, P687
[53]   DNA vaccines: safety and efficacy issues [J].
Klinman, DM ;
Takeno, M ;
Ichino, M ;
Gu, ML ;
Yamshchikov, G ;
Mor, G ;
Conover, J .
SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1997, 19 (02) :245-256
[54]   INDUCTION OF IMMUNE-RESPONSES IN PATIENTS WITH B-CELL LYMPHOMA AGAINST THE SURFACE-IMMUNOGLOBULIN IDIOTYPE EXPRESSED BY THEIR TUMORS [J].
KWAK, LW ;
CAMPBELL, MJ ;
CZERWINSKI, DK ;
HART, S ;
MILLER, RA ;
LEVY, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (17) :1209-1215
[55]   FIRST PEPTIDE VACCINE PROVIDING PROTECTION AGAINST VIRAL-INFECTION IN THE TARGET ANIMAL - STUDIES OF CANINE PARVOVIRUS IN DOGS [J].
LANGEVELD, JPM ;
CASAL, JI ;
OSTERHAUS, ADME ;
CORTES, E ;
DESWART, R ;
VELA, C ;
DALSGAARD, K ;
PUIJK, WC ;
SCHAAPER, WMM ;
MELOEN, RH .
JOURNAL OF VIROLOGY, 1994, 68 (07) :4506-4513
[56]  
LANGEVELD JPM, 2000, UNPUB ARCH VIROLOGY
[57]   Structure-based design of peptide presentation on a viral surface: The crystal structure of a plant/animal virus chimera at 2.8 angstrom resolution [J].
Lin, TW ;
Porta, C ;
Lomonossoff, G ;
Johnson, JE .
FOLDING & DESIGN, 1996, 1 (03) :179-187
[58]   THE SYNTHESIS AND STRUCTURE OF COMOVIRUS CAPSIDS [J].
LOMONOSSOFF, GP ;
JOHNSON, JE .
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1991, 55 (02) :107-137
[59]  
LOVGREN K, 1990, CLIN EXP IMMUNOL, V82, P435, DOI 10.1111/j.1365-2249.1990.tb05467.x
[60]   New treatment options for patients with melanoma: Review of melanoma-derived T-cell epitope-based peptide vaccines [J].
Maeurer, MJ ;
Storkus, WJ ;
Kirkwood, JM ;
Lotze, MT .
MELANOMA RESEARCH, 1996, 6 (01) :11-24
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