Cowpea mosaic virus as a vaccine carrier of heterologous antigens

被引：42
作者：
Brennan, FR
Jones, TD
Hamilton, WDO
机构：
[1] Proteom Ltd., Babraham Hall, Babrahm
来源：
MOLECULAR BIOTECHNOLOGY | 2001年 / 17卷 / 01期
关键词：
plant virus; chimeric virus particle; vaccine;
D O I：
10.1385/MB:17:1:15
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The plant virus, cowpea mosaic virus (CPMV), has been developed as an expression and presentation system to display antigenic epitopes: derived from a number of vaccine targets including infectious disease agents and tumors. These chimeric virus particles (CVPs) could represent a cost-effective and safe alternative to live replicating virus and bacterial vaccines. A number of CVPs have now been generated and their immunogenicity examined ill a number of animal species. This review details the humoral and cellular immune responses generated by these CVPs following both par-enteral and mucosal delivery and highlights the potential of CVPs to elicit protective immunity from both viral and bacterial infection.
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收藏
页码：15 / 26
页数：12
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