Vaccine effectiveness against infection and onwards transmission of COVID-19: Analysis of Belgian contact tracing data, January-June 2021

被引：30

作者：

Braeye, Toon ^{[1
]}

Cornelissen, Laura ^{[1
]}

Catteau, Lucy ^{[1
]}

Haarhuis, Freek ^{[1
]}

Proesmans, Kristiaan ^{[1
]}

De Ridder, Karin ^{[1
]}

Djiena, Achille ^{[2
]}

Mahieu, Romain ^{[3
]}

De Leeuw, Frances ^{[3
]}

Dreuw, Alex ^{[4
]}

Hammami, Naima ^{[5
]}

Quoilin, Sophie ^{[1
]}

Van Oyen, Herman ^{[1
]}

Wyndham-Thomas, Chloe ^{[1
]}

Van Cauteren, Dieter ^{[1
]}

机构：

[1] Sciensano, Dept Epidemiol & Publ Hlth, Brussels, Belgium

[2] Agence Vie Qualite, Charleroi, Belgium

[3] Common Community Commiss Brussels, Brussels, Belgium

[4] Minist German Speaking Community, Eupen, Belgium

[5] Agcy Care & Hlth Infect Prevent & Control, Flemish Community, Ghent, Belgium

来源：

VACCINE | 2021年 / 39卷 / 39期

关键词：

D O I：

10.1016/j.vaccine.2021.08.060

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In Belgium, high-risk contacts of an infected person were offered PCR-testing irrespective of their vacci-nation status. We estimated vaccine effectiveness (VE) against infection and onwards transmission, con-trolling for previous infections, household-exposure and temporal trends. We included 301,741 tests from 25 January to 24 June 2021. Full-schedule vaccination was associated with significant protection against infection. In addition, mRNA-vaccines reduced onward transmission: VE-estimates increased to >90% when index and contact were fully vaccinated. The small number of viral-vector vaccines included limited interpretability. (C) 2021 The Author(s). Published by Elsevier Ltd.

引用

页码：5456 / 5460

页数：5

共 15 条

[1] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[2] Covid-19 Breakthrough Infections in Vaccinated Health Care Workers [J].

Bergwerk, Moriah ;

Gonen, Tal ;

Lustig, Yaniv ;

Amit, Sharon ;

Lipsitch, Marc ;

Cohen, Carmit ;

Mandelboim, Michal ;

Gal Levin, Einav ;

Rubin, Carmit ;

Indenbaum, Victoria ;

Tal, Ilana ;

Zavitan, Malka ;

Zuckerman, Neta ;

Bar-Chaim, Adina ;

Kreiss, Yitshak ;

Regev-Yochay, Gili .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (16) :1474-1484

[3] Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant [J].

Bernal, Jamie Lopez ;

Andrews, Nick ;

Gower, Charlotte ;

Gallagher, Eileen ;

Simmons, Ruth ;

Thelwall, Simon ;

Stowe, Julia ;

Tessier, Elise ;

Groves, Natalie ;

Dabrera, Gavin ;

Myers, Richard ;

Campbell, Colin N. J. ;

Amirthalingam, Gayatri ;

Edmunds, Matt ;

Zambon, Maria ;

Brown, Kevin E. ;

Hopkins, Susan ;

Chand, Meera ;

Ramsay, Mary .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (07) :585-594

[4]

Bjork J, 2021, EFFECTIVENESS BNT162

[5] Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study [J].

Chia, Po Ying ;

Ong, Sean Wei Xiang ;

Chiew, Calvin J. ;

Ang, Li Wei ;

Chavatte, Jean-Marc ;

Mak, Tze-Minn ;

Cui, Lin ;

Kalimuddin, Shirin ;

Chia, Wan Ni ;

Tan, Chee Wah ;

Chai, Louis Yi Ann ;

Tan, Seow Yen ;

Zheng, Shuwei ;

Lin, Raymond Tzer Pin ;

Wang, Linfa ;

Leo, Yee-Sin ;

Lee, Vernon J. ;

Lye, David Chien ;

Young, Barnaby Edward .

CLINICAL MICROBIOLOGY AND INFECTION, 2022, 28 (04) :612.e1-612.e7

[6] Programming With Models: Writing Statistical Algorithms for General Model Structures With NIMBLE [J].

de Valpine, Perry ;

Turek, Daniel ;

Paciorek, Christopher J. ;

Anderson-Bergman, Clifford ;

Lang, Duncan Temple ;

Bodik, Rastislav .

JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS, 2017, 26 (02) :403-413

[7] Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data [J].

Haas, Eric J. ;

Angulo, Frederick J. ;

McLaughlin, John M. ;

Anis, Emilia ;

Singer, Shepherd R. ;

Khan, Farid ;

Brooks, Nati ;

Smaja, Meir ;

Mircus, Gabriel ;

Pan, Kaijie ;

Southern, Jo ;

Swerdlow, David L. ;

Jodar, Luis ;

Levy, Yeheskel ;

Alroy-Preis, Sharon .

LANCET, 2021, 397 (10287) :1819-1829

[8] Effect of Vaccination on Household Transmission of SARS-CoV-2 in England [J].

Harris, Ross J. ;

Hall, Jennifer A. ;

Zaidi, Asad ;

Andrews, Nick J. ;

Dunbar, J. Kevin ;

Dabrera, Gavin .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (08) :759-760

[9]

Ledford H, 2021, NATURE, V594, P164, DOI 10.1038/d41586-021-01505-x

[10]

Moustsen-Helms IR, 2021, VACCINE EFFECTIVENES

← 1 2 →