Role for Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in Hormone-Dependent Cancers

被引：46

作者：

Cheng, Meng ^{[1
]}

Michalski, Stephanie ^{[1
]}

Kommagani, Ramakrishna ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Obstet & Gynecol, Ctr Reprod Hlth Sci, St Louis, MO 63110 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 09期

基金：

美国国家卫生研究院;

关键词：

GREB1; steroid hormone; estrogen; progesterone; androgen; breast cancer; ovarian cancer; prostate cancer; HISTONE METHYLTRANSFERASE EZH2; STEROID-RECEPTOR COACTIVATOR-3; PROSTATE-CANCER; GENE-EXPRESSION; OVARIAN-CANCER; SERTOLI-CELLS; MAMMARY-GLAND; THERAPEUTIC TARGET; PROTEIN EXPRESSION; RESPONSE ELEMENTS;

D O I：

10.3390/ijms19092543

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sex hormones play important roles in the onset and progression of several cancers, such as breast, ovarian, and prostate cancer. Although drugs targeting sex hormone function are useful in treating cancer, tumors often develop resistance. Thus, we need to define the downstream effectors of sex hormones in order to develop new treatment strategies for these cancers. Recent studies unearthed one potential mediator of steroid hormone action in tumors: growth regulation by estrogen in breast cancer 1 (GREB1). GREB1 is an early estrogen-responsive gene, and its expression is correlated with estrogen levels in breast cancer patients. Additionally, GREB1 responds to androgen in prostate cancer cells, and can stimulate the proliferation of breast, ovarian, and prostate cancer cells. Recent studies have shown that GREB1 also responds to progesterone in human endometrial cells, suggesting that GREB1 is a pan steroid-responsive gene. This mini-review examines evidence that GREB1 participates in several hormone-dependent cancers and could be targeted to treat these cancers.

引用

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