CXCL13 as biomarker for histological involvement in Sjogren's syndrome

被引：35

作者：

Colafrancesco, Serena ^{[1
]}

Priori, Roberta ^{[1
]}

Smith, Charlotte G. ^{[2
]}

Minniti, Antonina ^{[1
]}

Iannizzotto, Valentina ^{[2
]}

Pipi, Elena ^{[2
]}

Lucchesi, Davide ^{[3
]}

Pontarini, Elena ^{[3
]}

Nayar, Saba ^{[2
]}

Campos, Joana ^{[2
]}

Arienzo, Francesca ^{[1
]}

Fusconi, Massimo ^{[4
]}

Cerbelli, Bruna ^{[5
]}

Giordano, Carla ^{[5
]}

Valesini, Guido ^{[1
]}

Bombardieri, Michele ^{[3
]}

Fisher, Benjamin A. ^{[2
,6
]}

Barone, Francesca ^{[2
,6
]}

机构：

[1] Sapienza Univ, Dipartimento Med Interna & Special Med, Rheumatol Unit, Rome, Italy

[2] Univ Birmingham, Inst Inflammat & Ageing, Rheumatol Res Grp, Birmingham, W Midlands, England

[3] Queen Mary Univ London, Ctr Expt Med & Rheumatol, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England

[4] Sapienza Univ Rome, Dept Sense Organs, Rome, Italy

[5] Sapienza Univ Rome, Dept Radiol Oncol & Pathol Sci, Rome, Italy

[6] Univ Hosp Birmingham NHS Fdn Trust, Birmingham Biomed Res Ctr, NIHR, Birmingham, W Midlands, England

来源：

RHEUMATOLOGY | 2020年 / 59卷 / 01期

基金：

欧盟地平线“2020”; 英国医学研究理事会;

关键词：

Sjogren's syndrome; biomarkers; histopathology; cytokines and inflammatory mediators; lymphocytes; ABATACEPT TREATMENT; LYMPHOMA; HISTOPATHOLOGY; INFLAMMATION; FEATURES;

D O I：

10.1093/rheumatology/kez255

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives. SS is an autoimmune condition characterized by systemic B-cell activation, autoantibody production and ectopic germinal centres' formation within the salivary gland (SG). The extent of SG infiltrate has been proposed as a biomarker of disease severity. Plasma levels of CXCL13 correlate with germinal centres' activity in animal models and disease severity in SS, suggesting its potential use as a surrogate serum marker to monitor local B-cell activation. The aim of this study was to evaluate the potential role of CXCL13 as a biomarker of SG pathology in two independent SS cohorts. Methods. 109 patients with SS were recruited at Sapienza University of Rome (Italy) (n = 60), or at Queen Elizabeth Hospital in Birmingham and Barts Health NHS Trust in London (n = 49). Both sera and matched minor SG biopsy were available. Sicca (n = 57) and healthy subjects' (n = 19) sera were used as control. Results. CXCL13 serum level was higher in SS patients compared with controls. Correlations between its serum levels and a series of histomorphological parameters, including size of the aggregates and the presence germinal centres', were observed. Conclusion. Our data foster the use of CXCL13 to monitor the extent of local pathology in SS and its validation in longitudinal clinical studies.

引用

页码：165 / 170

页数：6

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