Porous Poly(ethylene oxide) / Poly(L-lactic acid) Fiber Fabricated via Coaxial Electrospinning: Potential as Biomedical Applications

被引：0
作者：
Chankoa, Ramaimas [1 ]
Kreua-ongarjnukool, Narumol [1 ]
Supaphol, Pitt [2 ,3 ]
Pavasant, Prasit [4 ]
机构：
[1] King Mongkuts Univ Technol North Bangkok, Fac Sci Appl, Dept Ind Chem, Bangkok 10800, Thailand
[2] Chulalongkorn Univ, Petr & Petrochem Coll, Bangkok 10330, Thailand
[3] Chulalongkorn Univ, Ctr Excellence Petrochem & Mat Technol, Bangkok 10330, Thailand
[4] Chulalongkorn Univ, Fac Dent, Dept Anat, Bangkok 10330, Thailand
来源：
CHIANG MAI JOURNAL OF SCIENCE | 2014年 / 41卷 / 5.2期
关键词：
coaxial electrospinning; porous core-shell fiber mats; bovine serum albumin; DRUG-DELIVERY; NANOFIBERS; RELEASE; POLY(EPSILON-CAPROLACTONE); BLEND; MATS;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The conventional electrospinning setup was modified to utilize two separate coaxial delivery channels. This research focused on the fabrication of porous core-shell fibers by phase separation. Poly(L-lactic acid: PLLA) and Poly(ethylene oxide: PEO) were used to fabricate into shell and core layers, respectively. Phase separation was used to introduce porosity into the PLLA shell layer. Bovine serum albumin (BSA) was incorporated within the core layer through mixing with a PEO solution. The core-shell fibers and the BSA-incorporated core-shell fibers were characterized with regard to their physical, physico-chemical properties and release characteristic of BSA. The protein release rate can be controlled by adjusting the surface topography of core-shell fibers. The biological compatibility was evaluated by an indirect cytotoxicity test using murine pre-osteoblastic cells (MC3T3-E1). In conclusion, BSA-incorporated porous core-shell fibers were good candidates to be used as biomedical applications.
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页码：1301 / 1316
页数：16
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