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The Association of Dynamin with Synaptophysin Regulates Quantal Size and Duration of Exocytotic Events in Chromaffin Cells
被引:46
作者:

Gonzalez-Jamett, Arlek M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile

Baez-Matus, Ximena
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h-index: 0
机构:
Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile

Hevia, Montserrat A.
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h-index: 0
机构:
Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile

Jose Guerra, Maria
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h-index: 0
机构:
Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile

Jose Olivares, Maria
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile

Martinez, Agustin D.
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h-index: 0
机构:
Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile

Neely, Alan
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h-index: 0
机构:
Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile

Cardenas, Ana M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile
机构:
[1] Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 2340000, Chile
关键词:
SYNAPTIC VESICLE PROTEIN;
TRANSMITTER SECRETION;
MEMBRANE-PROTEIN;
GRANULES;
RELEASE;
ROLES;
MODE;
P38;
ENDOCYTOSIS;
EXPRESSION;
D O I:
10.1523/JNEUROSCI.5210-09.2010
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Although synaptophysin is one of the most abundant integral proteins of synaptic vesicle membranes, its contribution to neurotransmitter release remains unclear. One possibility is that through its association with dynamin it controls the fine tuning of transmitter release. To test this hypothesis, we took advantage of amperometric measurements of quantal catecholamine release from chromaffin cells. First, we showed that synaptophysin and dynamin interact in chromaffin granule-rich fractions and that this interaction relies on the C terminal of synaptophysin. Experimental maneuvers that are predicted to disrupt the association between these two proteins, such as injection of antibodies against dynamin or synaptophysin, or peptides homologous to the C terminal of synaptophysin, increased the quantal size and duration of amperometric spikes. In contrast, the amperometric current that precedes the spike remained unchanged, indicating that synaptophysin/dynamin association does not regulate the initial fusion event.
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页码:10683 / 10691
页数:9
相关论文
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