Metabolic Syndromes and Malignant Transformation: Where the Twain Shall Meet

被引：2
作者：
Bhagwat, Neha [1 ,2 ]
Levine, Ross L. [1 ,2 ,3 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA
[2] Mem Sloan Kettering Canc Ctr, Gerstner Sloan Kettering Sch Biomed Sci, New York, NY 10065 USA
[3] Mem Sloan Kettering Canc Ctr, Leukemia Serv, Dept Med, New York, NY 10065 USA
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2010年 / 2卷 / 54期
关键词：
D-2-HYDROXYGLUTARIC ACIDURIA; IDH2; MUTATIONS; LEUKEMIA; COMPLEX; CANCER; GENE;
D O I：
10.1126/scitranslmed.3001669
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recurrent somatic mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes that result in the accumulation of D-2-hydroxyglutarate (D-2-HG) have been identified in malignant gliomas and in acute myeloid leukemia (AML). However, the function of this metabolite in normal and malignant tissues remains uncertain. A report in the current issue of Science describes a germline IDH2 mutation in a subset of patients with a rare metabolic disorder-D-2-hydroxyglutaric aciduria-that is similar to mutations seen in cancer patients. These observations further elucidate the effects of IDH mutations on normal and malignant cells.
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