Promiscuity and preferences of metallothioneins: the cell rules

被引：34

作者：

Foster, Andrew W. ^{[1
]}

Robinson, Nigel J. ^{[1
]}

机构：

[1] Univ Durham, Biophys Sci Inst, Dept Chem, Sch Biol & Biomed Sci, Durham DH1 3LE, England

来源：

BMC BIOLOGY | 2011年 / 9卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

METAL; METALLOPROTEINS; SELECTIVITY; SENSITIVITY; BINDING;

D O I：

10.1186/1741-7007-9-25

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metalloproteins are essential for many cellular functions, but it has not been clear how they distinguish between the different metals to bind the correct ones. A report in BMC Biology finds that preferences of two metallothionein isoforms for two different cations are due to inherent properties of these usually less discriminating proteins. Here these observations are discussed in the context of the cellular mechanisms that regulate metal binding to proteins.

引用

页数：3

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