Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice

被引：40

作者：

Park, Eunjin ^{[1
,2
]}

Hwang, Insun ^{[1
,2
]}

Song, Jie-Young ^{[3
]}

Jee, Youngheun ^{[1
,2
]}

机构：

[1] Cheju Natl Univ, Coll Vet Med, Cheju 690756, South Korea

[2] Cheju Natl Univ, Appl Radiol Sci Res Inst, Cheju 690756, South Korea

[3] Korea Inst Radiol & Med Sci, Lab Radiat Immunol, Seoul 139706, South Korea

来源：

ACTA HISTOCHEMICA | 2011年 / 113卷 / 01期

关键词：

Acidic polysaccharide; Panax ginseng; Ionizing radiation; Apoptosis; Radioprotection; Small intestine; Mice; IONIZING-RADIATION; INDUCED APOPTOSIS; EPITHELIAL-CELLS; BONE-MARROW; STEM-CELLS; RADIOPROTECTION; EXTRACT; GINSAN; MOUSE; P53;

D O I：

10.1016/j.acthis.2009.07.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An acidic polysaccharide of Panax ginseng (APG), ginsan, has been reported to protect the hematopoietic system by increasing the number of bone marrow cells and spleen cells. Therefore, we evaluated the ability of APG to protect mice from radiation-induced damage of the small intestine. APG treatment caused the lengthening of villi and a numerical increase of crypt cells in the small intestine at 3.5 days after 7 Gy irradiation compared to irradiated, non-treated controls. In addition, APG significantly inhibited irradiation-induced apoptosis by decreasing the amount of pro-apoptotic p53 and Bax as well as augmenting that of anti-apoptotic Bcl-2 at 24 h after irradiation. These results indicate that APG might be a useful adjunct to therapeutic irradiation as a protective agent for the gastrointestinal tract of cancer patients. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：19 / 23

页数：5

共 23 条

[1] BEHAVIORAL TOXICITY AND EFFICACY OF WR-2721 AS A RADIOPROTECTANT
BOGO, V
JACOBS, AJ
WEISS, JF
[J]. RADIATION RESEARCH, 1985, 104 (02) : 182 - 190
[2] IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation
Chen, Tingchao
Burke, Kathleen A.
Zhan, Yuxia
Wang, Xingchao
Shibata, Darryl
Zhao, Yi
[J]. EXPERIMENTAL HEMATOLOGY, 2007, 35 (02) : 203 - 213
[3] Radioprotection of DNA by glycyrrhizic acid through scavenging free radicals
Gandhi, NM
Maurya, DK
Salvi, V
Kapoor, S
Mukherjee, T
Nair, CKK
[J]. JOURNAL OF RADIATION RESEARCH, 2004, 45 (03) : 461 - 468
[4] Podophyllum hexandrum modulates gamma radiation-induced immunosuppression in Balb/c mice:: Implications in radioprotection
Goel, H. C.
Prakash, H.
Ali, A.
Bala, M.
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2007, 295 (1-2) : 93 - 103
[5] Radioprotective potential of an herbal extract of Tinospora cordifolia
Goel, HC
Prasad, J
Singh, S
Sagar, RK
Agrawala, PK
Bala, M
Sinha, AK
Dogra, R
[J]. JOURNAL OF RADIATION RESEARCH, 2004, 45 (01) : 61 - 68
[6] Modulation of radiation-induced disturbances of antioxidant defense systems by ginsan
Han, Y
Son, SJ
Akhalaia, M
Platonov, A
Son, HJ
Lee, KH
Yun, YS
Song, JY
[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2005, 2 (04) : 529 - 536
[7] p53 and cell-cycle-regulated protein expression in small intestinal cells after fast-neutron irradiation in mice
Jee, YH
Jeong, WI
Kim, TH
Hwang, IS
Ahn, MJ
Joo, HG
Hong, SH
Jeong, KS
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2005, 270 (1-2) : 21 - 28
[8] Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells
Kim, Hyun-Ji
Kim, Mi-Hyoung
Byon, Yun-Young
Park, Jae Woo
Jee, Youngheun
Joo, Hong-Gu
[J]. JOURNAL OF VETERINARY SCIENCE, 2007, 8 (01) : 39 - 44
[9] Kim SR, 2003, IN VIVO, V17, P77
[10] EFFECT OF IMMUNOCHEMOTHERAPY ON LYMPHOCYTE-RESPONSE OF PATIENTS WITH GASTRO-INTESTINAL CANCER
MASHIBA, H
YOSHINAGA, H
MATSUNAGA, K
GOJOBORI, M
FURUSAWA, M
[J]. JOURNAL OF SURGICAL ONCOLOGY, 1979, 12 (03) : 275 - 279

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