Sncl2-catalyzed synthesis of dihydropyrimidinones under solvent-free conditions

被引:0
作者
Singh, Okram M. [1 ]
Singh, M. Lokeshwar [1 ]
Singh, S. Joychandra [1 ]
机构
[1] Manipur Univ, Dept Chem, Imphal 795003, Manipur, India
关键词
dihydropyrimidines; biginelli; stannous chloride; solvent-free;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A simple, efficient and practical green synthetic route to the Biginelli cyclocondensation reaction using Stannous (II) Chloride Dihydrate as the catalyst is described under solvent free conditions to yield dihydropyrimidinones in high yields.
引用
收藏
页码:277 / 282
页数:6
相关论文
共 18 条
[1]   The tethered Biginelli condensation in natural product synthesis [J].
Aron, ZD ;
Overman, LE .
CHEMICAL COMMUNICATIONS, 2004, (03) :253-265
[2]   DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .3. 3-CARBAMOYL-4-ARYL-1,2,3,4-TETRAHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS ORALLY EFFECTIVE ANTIHYPERTENSIVE AGENTS [J].
ATWAL, KS ;
SWANSON, BN ;
UNGER, SE ;
FLOYD, DM ;
MORELAND, S ;
HEDBERG, A ;
OREILLY, BC .
JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :806-811
[3]  
Barluenga J., 1995, CHEM COMMUN, P1369
[4]   Recent advances in solventless organic reactions: towards benign synthesis with remarkable versatility [J].
Cave, GWV ;
Raston, CL ;
Scott, JL .
CHEMICAL COMMUNICATIONS, 2001, (21) :2159-2169
[5]  
FAUL MM, 1995, ENCY REAGENTS ORGANI, V7, P4893
[6]  
Fieser L.F., 1967, REAGENTS ORGANIC SYN, P1113
[7]   The guanidine metabolites of Ptilocaulis spiculifer and related compounds; isolation and synthesis [J].
Heys, L ;
Moore, CG ;
Murphy, PJ .
CHEMICAL SOCIETY REVIEWS, 2000, 29 (01) :57-67
[8]   The generation of dihydropyrimidine libraries utilizing Biginelli multicomponent chemistry [J].
Kappe, CO .
QSAR & COMBINATORIAL SCIENCE, 2003, 22 (06) :630-645
[9]   Biologically active dihydropyrimidones of the Biginelli-type - a literature survey [J].
Kappe, CO .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (12) :1043-1052
[10]  
Lu J., 2000, SYNLETT, V63