In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis

被引：7

作者：

Xin, Qi ^{[1
]}

Yuan, Miaomiao ^{[1
,2
]}

Li, Huanping ^{[1
]}

Song, Xiaoxia ^{[1
]}

Lu, Jun ^{[1
]}

Jing, Tao ^{[1
]}

机构：

[1] Lanzhou Univ, Inst Pathogen Biol, Sch Basic Med Sci, Lanzhou, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 8, Shenzhen, Peoples R China

来源：

VETERINARY RESEARCH | 2020年 / 51卷 / 01期

关键词：

EHRLICH ASCITES TUMOR; AGENT LONIDAMINE; INHIBITION; ALVEOLAR; PRAZIQUANTEL; COMBINATION; RESPIRATION; METABOLISM;

D O I：

10.1186/s13567-020-00744-6

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E. granulosussensu stricto (s. s.) and E. multilocularis. The combination of LND and 6-AN exhibited a significantly higher activity than the single drug treatment. These results highlight the therapeutic potential of LND, 6-AN and the combination of LND and 6-AN for the treatment of echinococcosis.

引用

页数：7

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