Severe attacks of familial hemiplegic migraine, childhood epilepsy and ATP1A2 mutation

被引：30

作者：

Lebas, A. ^{[1
]}

Guyant-Marechal, L. ^{[2
]}

Hannequin, D.

Riant, F. ^{[4
]}

Tournier-Lasserve, E. ^{[4
]}

Parain, D. ^{[3
]}

机构：

[1] Rouen Univ Hosp, Dept Paediat, F-76230 Rouen, France

[2] Rouen Univ Hosp, Dept Neurol, F-76230 Rouen, France

[3] Rouen Univ Hosp, Dept Neurophysiol, F-76230 Rouen, France

[4] Groupement Hosp Univ Nord, Dept Genet, AP HP, Grp Hosp Lariboisiere Fernand Widal, Paris, France

来源：

CEPHALALGIA | 2008年 / 28卷 / 07期

关键词：

ATP1A2; gene; childhood absence epilepsy; childhood epilepsy; familial hemiplegic migraine;

D O I：

10.1111/j.1468-2982.2008.01603.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied four members of a family suffering from typical attacks of familial hemiplegic migraine (FHM) caused by a new mutation, R548C, of ATP1A2 gene in exon 12. One individual had also childhood absence epilepsy and generalized tonic-clonic seizures (GTCS). GTCS were followed by a severe attack of hemiplegic migraine at four times. Sodium valproate enabled control of both the epileptic seizures and the most severe FHM attacks. This association of FHM and epileptic seizures and their control with the same treatment suggest similar pathophysiological mechanisms.

引用

页码：774 / 777

页数：4

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