Nonalcoholic Fatty Liver Disease Is a Precursor of New-Onset Metabolic Syndrome in Metabolically Healthy Young Adults

被引：12

作者：

Yoo, Jeong-Ju ^{[1
]}

Cho, Eun Ju ^{[2
,3
]}

Chung, Goh Eun ^{[4
,5
]}

Chang, Young ^{[6
]}

Cho, Yuri ^{[7
]}

Park, Sang-Hyun ^{[8
]}

Jeong, Su-Min ^{[9
,10
]}

Kim, Bo-Yeon ^{[11
]}

Shin, Dong Wook ^{[9
,10
,12
,13
]}

Kim, Yun Joon ^{[2
,3
]}

Yoon, Jung-Hwan ^{[2
,3
]}

Han, Kyungdo ^{[8
]}

Yu, Su Jong ^{[2
,3
]}

机构：

[1] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Bucheon 14584, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 03080, South Korea

[3] Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul 03080, South Korea

[4] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Internal Med, Seoul 06236, South Korea

[5] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Inst Healthcare Res, Seoul 06236, South Korea

[6] Soonchunhyang Univ, Seoul Hosp, Dept Gastroenterol & Hepatol, Seoul 04401, South Korea

[7] Natl Canc Ctr, Ctr Liver & Pancreatobiliary Canc, Goyang 10408, South Korea

[8] Soongsil Univ, Coll Med, Dept Biostat, Seoul 06978, South Korea

[9] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Family Med, Seoul 06351, South Korea

[10] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Support Care Ctr, Seoul 06351, South Korea

[11] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Div Endocrinol, Bucheon 14584, South Korea

[12] Samsung Adv Inst Hlth Sci, Dept Clin Res Design & Evaluat, Seoul 06355, South Korea

[13] Samsung Adv Inst Hlth Sci, Dept Digital Hlth, Seoul 06355, South Korea

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 04期

关键词：

metabolic syndrome; nonalcoholic fatty liver disease; fatty liver index; INSULIN-RESISTANCE; KOREAN MEN; DYSLIPIDEMIA; PREVALENCE; CHILDREN; MUSCLE; RISK;

D O I：

10.3390/jcm11040935

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome (MetS). However, the temporal relationship between NAFLD and MetS has yet to be evaluated, especially in young adults. In this study, we investigated whether NAFLD could be a precursor for MetS in metabolically healthy young adults. Using the Korean nationwide health screening database, we analyzed subjects aged 20-39 years who were free from any component of MetS between 2009 and 2012. A total of 1,659,192 subjects without excessive alcohol consumption or concomitant liver disease were categorized into three groups according to the fatty liver index (FLI): (1) NAFLD (FLI >= 60); (2) borderline NAFLD (30 <= FLI < 60); and (3) control (FLI < 30). During the 6,699,462 person-years of follow-up, 109,239 subjects developed MetS (16.3 per 1000-person-years). The NAFLD group and the borderline NAFLD group were associated with a higher risk of MetS than the control group (incidence rate ratios, 2.9 (95% confidence interval (CI), 2.7-3.1) for the NAFLD group and 2.1 (95% CI, 2.1-2.2) for the borderline NAFLD group, respectively). In addition, all of the metabolic components were positively associated with FLI in a proportional manner. NAFLD is associated with the future onset of MetS in young adults. Therefore, active lifestyle intervention is required for young adults diagnosed with NAFLD to prevent MetS and other metabolic diseases.

引用

页数：10

共 42 条

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