Glycocalyx in vivo measurement

被引：26

作者：

Cerny, Vladimir ^{[1
,2
,3
,4
]}

Astapenko, David ^{[2
,3
]}

Burkovskiy, Ian ^{[4
,7
]}

Hyspler, Radomir ^{[2
]}

Ticha, Alena ^{[2
]}

Trevors, Mary Ann ^{[5
]}

Lehmann, Christian ^{[4
,6
,7
,8
]}

机构：

[1] Univ JE Purkyne, Masaryk Hosp, Dept Anaesthesiol Perioperat Med & Intens Care, Usti Nad Labem, Czech Republic

[2] Univ Hosp Hradec Kralove, Ctr Res & Dev, Hradec Kralove, Czech Republic

[3] Charles Univ Prague, Fac Med, Dept Anaesthesiol & Intens Care, Hradec Kralove, Czech Republic

[4] Dalhousie Univ, Dept Anaesthesia Pain Management & Perioperat Med, Halifax, NS, Canada

[5] Dalhousie Univ, Fac Med, Electron Microscopy Unit, Core Facil, Halifax, NS, Canada

[6] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS, Canada

[7] Dalhousie Univ, Dept Pharmacol, Halifax, NS, Canada

[8] Dalhousie Univ, Dept Physiol & Biophys, Halifax, NS, Canada

来源：

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | 2017年 / 67卷 / 3-4期

关键词：

Endothelial glycocalyx; laboratory methods; videomicroscopy; Perfused Boundary Region; ENDOTHELIAL GLYCOCALYX; VASCULAR ENDOTHELIUM; BARRIER; HEALTH; SODIUM;

D O I：

10.3233/CH-179235

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The endothelial glycocalyx (EG) lining the endoluminal surface of the capillaries has been proposed as a key component of the microcirculation and a major player in microvascular pathology. Recent advances in the understanding of its physiological role and clinical significance have been made upon the development of methods allowing EG assessment in clinical medicine. Laboratory methods can assess the amount of EG damage by measuring levels of its degradation products (e.g. syndecan-1, heparan sulphate and hyaluronan sulphate), mostly in the plasma, however, their physiological turnover disqualifies them from being the reliable index of EG damage. At the bedside, in vivo video microscopy tools technologies (e.g. Side-stream Dark Field imaging technology) allow indirect assessment of EG thickness in sublingual microcirculation by measuring the penetration extent (called Perfused Boundary Region) of flowing red blood cells into the EG.

引用

页码：499 / 503

页数：5

共 20 条

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