Liver injury suppressing compounds from Avocado (Persea americana)

被引：59

作者：

Kawagishi, H

Fukumoto, Y

Hatakeyama, M

He, PM

Arimoto, H

Matsuzawa, T

Arimoto, Y

Suganuma, H

Inakuma, T

Sugiyama, K

机构：

[1] Shizuoka Univ, Fac Agr, Dept Appl Biochem, Oya, Shizuoka 4228529, Japan

[2] Shizuoka Univ, Fac Sci, Dept Chem, Oya, Shizuoka 4228529, Japan

[3] Kagome Co Ltd, Res Inst, Nishinsauno, Tochigi 3292762, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2001年 / 49卷 / 05期

关键词：

liver injury suppression; fatty acid derivative; avocado; Persea americana;

D O I：

10.1021/jf0015120

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

To evaluate the protective activity of fruits against liver injury, 22 different fruits were :fed :to rats with liver damage caused by D-galactosamine, a powerful liver toxin; As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z, 15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z;15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.

引用

收藏

页码：2215 / 2221

页数：7

相关论文

共 16 条

[1] ISOLATION AND STRUCTURE ELUCIDATION OF GROWTH-INHIBITORS FOR SILKWORM LARVAE FROM AVOCADO LEAVES [J].

CHANG, CF ;

ISOGAI, A ;

KAMIKADO, T ;

MURAKOSHI, S ;

SAKURAI, A ;

TAMURA, S .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1975, 39 (05) :1167-1168

[2] GALACTOSAMINE HEPATITIS - KEY ROLE OF THE NUCLEOTIDE DEFICIENCY PERIOD IN THE PATHOGENESIS OF CELL INJURY AND CELL-DEATH [J].

DECKER, K ;

KEPPLER, D .

REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY, 1974, 71 :77-106

[3]

DUCAN DB, 1957, BIOMETRICS, V13, P164

[4] PREPARATION OF IODOALLYLIC ALCOHOLS VIA HYDROSTANNYLATION - SPECTROSCOPIC PROOF OF STRUCTURES [J].

JUNG, ME ;

LIGHT, LA .

TETRAHEDRON LETTERS, 1982, 23 (38) :3851-3854

[5] EXPERIMENTAL HEPATITIS INDUCED BY D-GALACTOSAMINE [J].

KEPPLER, D ;

LESCH, R ;

REUTTER, W ;

DECKER, K .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1968, 9 (02) :279-&

[6] Inhibition by (-)-persenone A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes [J].

Kim, OK ;

Murakami, A ;

Nakamura, Y ;

Kim, HW ;

Ohigashi, H .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2000, 64 (11) :2500-2503

[7] Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit [J].

Kim, OK ;

Murakami, A ;

Nakamura, Y ;

Takeda, N ;

Yoshizumi, H ;

Ohigashi, H .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (05) :1557-1563

[8] An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin [J].

Kim, OK ;

Murakami, A ;

Takahashi, D ;

Nakamura, Y ;

Torikai, K ;

Kim, HW ;

Ohigashi, H .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2000, 64 (11) :2504-2507

[9] Suppression of D-galactosamine-induced liver injury by mushrooms in rats [J].

Lee, EW ;

He, PM ;

Kawagishi, H ;

Sugiyama, K .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2000, 64 (09) :2001-2004

[10] A SHORT ENANTIOSELECTIVE SYNTHESIS OF A BIOLOGICALLY-ACTIVE COMPOUND FROM PERSEA-AMERICANA [J].

MACLEOD, JK ;

SCHAFFELER, L .

JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1995, 58 (08) :1270-1273