Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly

被引:13
|
作者
Burns, Jonathan R. [1 ]
Zekonyte, Jurgita [2 ]
Siligardi, Giuliano [3 ]
Hussain, Rohanah [3 ]
Stulz, Eugen [1 ]
机构
[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
[2] Univ Southampton, Natl Ctr Adv Tribol, Sch Engn Sci, Southampton SO17 1BJ, Hants, England
[3] Diamond Light Source, Didcot OX11 0DE, Oxon, England
基金
英国工程与自然科学研究理事会;
关键词
terpy-DNA; AFM; TEM; DNA nanotubes; PORPHYRIN ARRAYS; FORCE MICROSCOPY; LABEL-FREE; OLIGONUCLEOTIDES; RNA; NANOSTRUCTURES; HYBRIDIZATION; PURIFICATION; INFORMATION; TETRAHEDRON;
D O I
10.3390/molecules16064912
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.
引用
收藏
页码:4912 / 4922
页数:11
相关论文
共 50 条
  • [1] Protein nanoarrays - Aptamer-directed self-assembly of protein arrays on a DNA nanostructure
    Liu, Y
    Lin, CX
    Li, HY
    Yan, H
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (28) : 4333 - 4338
  • [2] Fabrication of Si and Ge nanoarrays through graphoepitaxial directed hardmask block copolymer self-assembly
    Gangnaik, Anushka S.
    Ghoshal, Tandra
    Georgiev, Yordan M.
    Morris, Michael A.
    Holmes, Justin D.
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2018, 531 : 533 - 543
  • [3] Self-assembly of symmetric finite-size DNA nanoarrays
    Liu, Y
    Ke, YG
    Yan, H
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (49) : 17140 - 17141
  • [4] Directed Self-Assembly of Diblock Copolymer Thin Films on Prepatterned Metal Nanoarrays
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Graduate School, Chinese Academy of Sciences, Changchun
    130022, China
    Macromol. Rapid Commun., 2 (161-167):
  • [5] Directed Self-Assembly of Diblock Copolymer Thin Films on Prepatterned Metal Nanoarrays
    Chang, Tongxin
    Huang, Haiying
    He, Tianbai
    MACROMOLECULAR RAPID COMMUNICATIONS, 2016, 37 (02) : 161 - 167
  • [6] Advances in square arrays through self-assembly and directed self-assembly of block copolymers
    Hardy, Christopher G.
    Tang, Chuanbing
    JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2013, 51 (01) : 2 - 15
  • [7] Directed Self-Assembly
    Sanders, Daniel P.
    Arnold, William H.
    JOURNAL OF MICRO-NANOLITHOGRAPHY MEMS AND MOEMS, 2012, 11 (03):
  • [8] Directed self-assembly
    Furst, Eric M.
    SOFT MATTER, 2013, 9 (38) : 9039 - 9045
  • [9] Directed Self-Assembly of DNA Tiles into Complex Nanocages
    Tian, Cheng
    Li, Xiang
    Liu, Zhiyu
    Jiang, Wen
    Wang, Guansong
    Mao, Chengde
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (31) : 8041 - 8044
  • [10] DNA Directed Self-Assembly of Anisotropic Plasmonic Nanostructures
    Pal, Suchetan
    Deng, Zhengtao
    Wang, Haining
    Zou, Shengli
    Liu, Yan
    Yan, Hao
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (44) : 17606 - 17609