Temperature, Oxygen, and Salt-Sensing Neurons in C. elegans Are Carbon Dioxide Sensors that Control Avoidance Behavior

被引：104

作者：

Bretscher, Andrew Jonathan ^{[1
]}

Kodama-Namba, Eiji ^{[1
]}

Busch, Karl Emanuel ^{[1
]}

Murphy, Robin Joseph ^{[1
]}

Soltesz, Zoltan ^{[1
]}

Laurent, Patrick ^{[1
]}

de Bono, Mario ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

来源：

NEURON | 2011年 / 69卷 / 06期

基金：

英国医学研究理事会; 瑞士国家科学基金会;

关键词：

NEMATODE CAENORHABDITIS-ELEGANS; NUCLEOTIDE-GATED CHANNEL; NERVOUS-SYSTEM; CHEMOSENSORY RECEPTORS; THERMOSENSORY NEURONS; GUANYLATE-CYCLASE; NATURAL VARIATION; DROSOPHILA; CO2; ANHYDRASE;

D O I：

10.1016/j.neuron.2011.02.023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Homeostatic control of body fluid CO2 is essential in animals but is poorly understood. C. elegans relies on diffusion for gas exchange and avoids environments with elevated CO2. We show that C. elegans temperature, O-2, and salt-sensing neurons are also CO2 sensors mediating CO2 avoidance. AFD thermosensors respond to increasing CO2 by a fall and then rise in Ca2+ and show a Ca2+ spike when CO2 decreases. BAG O-2 sensors and ASE salt sensors are both activated by CO2 and remain tonically active while high CO2 persists. CO2-evoked Ca2+ responses in AFD and BAG neurons require cGMP-gated ion channels. Atypical soluble guanylate cyclases mediating O-2 responses also contribute to BAG CO2 responses. AFD and BAG neurons together stimulate turning when CO2 rises and inhibit turning when CO2 falls. Our results show that C. elegans senses CO2 using functionally diverse sensory neurons acting homeostatically to minimize exposure to elevated CO2.

引用

页码：1099 / 1113

页数：15

共 64 条

[1] CHEMOSENSORY NEURONS WITH OVERLAPPING FUNCTIONS DIRECT CHEMOTAXIS TO MULTIPLE CHEMICALS IN C-ELEGANS [J].