Genetic and Molecular Basis of Inflammasome-mediated Disease

[21] Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (19) : 8041 - 8046

[22] Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome [J]. JOURNAL OF IMMUNOLOGY, 2009, 182 (10) : 6460 - 6469

[23] Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants [J]. NATURE, 2008, 453 (7198) : 1122 - U13

[24] Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (01) : 198 - 203

[25] The inflammasome mediates UVB-Induced activation and secretion of interleukin-1β by keratinocytes [J]. CURRENT BIOLOGY, 2007, 17 (13) : 1140 - 1145

[26] Ferrari D, 1997, J IMMUNOL, V159, P1451

[27] The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (08) : 2085 - 2089

[28] Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation [J]. JOURNAL OF IMMUNOLOGY, 2009, 183 (02) : 792 - 796

[29] Variant chronic infantile neurologic, cutaneous, articular syndrome due to a mutation within the leucine-rich repeat domain of CIAS1 [J]. ARTHRITIS AND RHEUMATISM, 2004, 50 (08): : 2719 - 2720

[30] Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179 (10) : 903 - 913

[21] Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (19) : 8041 - 8046

[22] Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome [J]. JOURNAL OF IMMUNOLOGY, 2009, 182 (10) : 6460 - 6469

[23] Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants [J]. NATURE, 2008, 453 (7198) : 1122 - U13

[24] Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (01) : 198 - 203

[25] The inflammasome mediates UVB-Induced activation and secretion of interleukin-1β by keratinocytes [J]. CURRENT BIOLOGY, 2007, 17 (13) : 1140 - 1145

[26] Ferrari D, 1997, J IMMUNOL, V159, P1451

[27] The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (08) : 2085 - 2089

[28] Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation [J]. JOURNAL OF IMMUNOLOGY, 2009, 183 (02) : 792 - 796

[29] Variant chronic infantile neurologic, cutaneous, articular syndrome due to a mutation within the leucine-rich repeat domain of CIAS1 [J]. ARTHRITIS AND RHEUMATISM, 2004, 50 (08): : 2719 - 2720

[30] Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179 (10) : 903 - 913